Drug Combination Details
| General Information of the Combination (ID: C74039) | |||||
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| Name | Reserpine | + | Mitoxantrone + Verapamil | ||
| Click to Show/Hide the Each NP or Drug Information of This Combination | |||||
| Name | Reserpine NP Info | Drug Info | |||
| Structure |
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| Name | Drug Info | ||||
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| Disease |
Melanoma
[ICD-11: 2C30]
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Investigative | [1] | ||
| Combinatorial Therapeutic Effect(s) Validated Clinically or Experimentally | ||||||
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| α. Decreasing Adverse Drug Reaction by This Combination | ||||||
| Decreasing Adverse Drug Reaction | Click to Show/Hide | |||||
| Experiment 1 Reporting the Effect of This Combination | [1] | |||||
| Molecule(s)
Regulation |
Up-regulation | Expression | CD80 | Molecule Info |
Pathway MAP
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| Up-regulation | Expression | HLA-DRB5 | Molecule Info |
Pathway MAP
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| Up-regulation | Expression | KLRK1 | Molecule Info |
Pathway MAP
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| In-vitro Model | YAC-1 | CVCL_2244 | Mouse lymphoma | Mus musculus | ||
| B16-F10 | CVCL_0159 | Mouse melanoma | Mus musculus | |||
| In-vivo Model | For a xenograft model, Female C57BL/6 mice, 6-8 weeks of age, 18-20 g, were subcutaneously (s.c.) immunized in the abdominal region with 2x105, 5x105 or 1x106 B16F10 cells. | |||||
| Experimental
Result(s) |
The B16F10 tumor cell vaccine treated with MIP in combination with RP and VP was safe and efficient. | |||||
