Drug Combination Details
| General Information of the Combination (ID: C74113) | |||||
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| Name | Vitamin C + Vitamin E | + | S-adenosylmethionine | ||
| Click to Show/Hide the Each NP or Drug Information of This Combination | |||||
| Name | Vitamin C NP Info | Drug Info | |||
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| Name | Vitamin E NP Info | ||||
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| Disease |
Liver injury
[ICD-11: NB91]
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Investigative | [1] | ||
| Combinatorial Therapeutic Effect(s) Validated Clinically or Experimentally | ||||||
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| α. Decreasing Adverse Drug Reaction by This Combination | ||||||
| Decreasing Adverse Drug Reaction | Click to Show/Hide | |||||
| Experiment 1 Reporting the Effect of This Combination | [1] | |||||
| In-vivo Model | Male C57BL/6 mice between 8-10 weeks were injected with DMSO, 15 mg/kg doxorubicin, or doxorubicin plus 25 mg/kg visnagin or 10 mg/kg diphenylurea intraperitoneally (n=4-5 each). | |||||
| Experimental
Result(s) |
There are synergistic antioxidative effects among the antioxidants, SAMe and vitamins C and E, that protect the liver from TAA-induced HDIR, suggesting that antioxidant treatment may best be done using a balanced "cocktail.". | |||||
| References | ||||
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| Reference 1 | Synergistic protection by S-adenosylmethionine with vitamins C and E on liver injury induced by thioacetamide in rats. Free Radic Biol Med. 2006 Feb 15;40(4):617-24. | |||
