Natural Product (NP) Details

General Information of the NP (ID: NP1339)
Name
Vitamin C
Synonyms
ascorbic acid; vitamin C; l-ascorbic acid; 50-81-7; L(+)-Ascorbic acid; ascorbate; Cevitamic acid; Ascoltin; Ascorbicap; Cenolate; Natrascorb; Hybrin; Allercorb; Ascorbajen; Ascorbutina; Ascorteal; Cescorbat; Cetemican; Cevitamin; Citriscorb; Laroscorbine; Lemascorb; Proscorbin; Roscorbic; Secorbate; Testascorbic; Vitacimin; Vitamisin; Vitascorbol; Ascorin; Ascorvit; Cantaxin; Cebicure; Cebione; Cegiolan; Ceglion; Celaskon; Cemagyl; Cenetone; Cergona; Cetamid; Cevalin; Cevatine; Cevimin; Cevital; Cevitan; Cevitex; Colascor; Concemin; Redoxon; Vicelat; Viforcit; Viscorin; Vitacee; Vitacin; Adenex; Ascorb; Cantan; Cebid; Cebion; Cecon; Cemill; Cereon; Cevex; Ciamin; Cipca; Hicee; Ribena; Vitace; Xitix; L-ascorbate; Davitamon C; Arco-cee; Planavit C; Catavin C; Ce lent; Liqui-Cee; Vicomin C; Cee-Vite; Cevi-Bid; Scorbu-C; C-Level; C-Vimin; Cetane-Caps TD; Duoscorb; Scorbacid; Cewin; Antiscorbic vitamin; C-Long; C-Quin; C-Span; Meri-C; Cee-Caps TD; L-Lyxoascorbic acid; L-Xyloascorbic acid; Antiscorbutic vitamin; Cetane-Caps TC; 3-Oxo-L-gulofuranolactone; Ce-Mi-Lin; IDO-C; Natrascorb injectable; L-(+)-Ascorbic Acid; CE-VI-Sol; Ferrous ascorbate; Acidum ascorbinicum; Ascor-B.I.D.; Acidum ascorbicum; Celin; Dora-C-500; Kyselina askorbova; 3-Keto-L-gulofuranolactone; Cortalex; Ferancee; Stuartinic; Tolfrinic; (R)-5-((S)-1,2-dihydroxyethyl)-3,4-dihydroxyfuran-2(5H)-one; Acido ascorbico; Acide ascorbique; Antiscorbutic factor; L-3-Ketothreohexuronic acid lactone; L-Threoascorbic acid; Chromagen; Kyselina askorbova [Czech]; Caswell No. 061B; Vicin; Acide ascorbique [INN-French]; Acido ascorbico [INN-Spanish]; Acidum ascorbicum [INN-Latin]; Sodascorbate; Ascorbicin; NCI-C54808; L-threo-Hex-2-enonic acid, gamma-lactone; L-threo-Ascorbic acid; FEMA No. 2109; 3-Oxo-L-gulofuranolactone (enol form); UNII-PQ6CK8PD0R; monodehydro-L-ascorbic acid; MFCD00064328; Cetebe; Ascorbin; (+)-Ascorbic acid; Hex-2-enonic acid gamma-lactone, L-threo-; Iron(II) ascorbate; PQ6CK8PD0R; component of E and C-Level; component of Endoglobin Forte; Vasc; Ascorbicab; CHEBI:29073; CCRIS 57; component of Cortalex; component of Ferancee; HSDB 818; NCGC00164357-01; E300; DSSTox_CID_106; E-300; hex-1-enofuranos-3-ulose; Iron-ascorbic acid complexes; DSSTox_RID_75370; DSSTox_GSID_20106; Kangbingfeng; Chewcee; Citrovit; Juvamine; 6730-29-6; Ceklin; L(+)-Ascorbic acid, 99%; (+)-Sodium L-ascorbate; Rovimix C; Scorbu C; Ascorbinsaeure; Parentrovite; Cell C; L(+)-Ascorbic acid, ACS reagent; Viscorin 100M; (2R)-2-[(1S)-1,2-dihydroxyethyl]-3,4-dihydroxy-2H-furan-5-one; Ronotec 100; Suncoat VC 40; (5R)-5-[(1S)-1,2-dihydroxyethyl]-3,4-dihydroxy-2,5-dihydrofuran-2-one; Rontex 100; Ascorbicap (TN); Xyloascorbic acid, L-; Ascoltin (TN); [14C]ascorbic acid; Ascorbic acid [BAN:INN:JAN]; Vitamin C (Ascorbic acid); [14C]-ascorbic acid; ascorbic acid (vit C); L-Ascorbic acid, meets USP testing specifications; 2-(1,2-Dihydroxyethyl)-4,5-dihydroxyfuran-3-one; 299-36-5; EINECS 200-066-2; NSC 33832; Cevitamate; Ascor; L-lyxoascorbate; L-xyloascorbate; .Ascorbinsaure; NSC-33832; Vitamin B mixture with vitamin C; 3eka; NSC-218455; Ester C; Ester-C; (+)-ascorbate; L(+)-ascorbate; L-threo-hex-2-enono-1,4-lactone; L-Ascorbic acid, free radical form; L-(+)-ascorbate; Ascorbic acid [USP:INN:BAN:JAN]; Ascorbic acid mixture with Vitamin B; Vitamin C,(S); E 300; 178101-88-7; PubChem18445; Ascorbic Acid DC97SF; (2R)-2-[(1S)-1,2-dihydroxyethyl]-4,5-dihydroxyfuran-3-one; (5R)-5-[(1S)-1,2-dihydroxyethyl]-3,4-dihydroxyfuran-2(5H)-one; Prestwick3_000325; L-Ascorbic acid, 99%; Ascorbic Acid mixture with Vitamin B Complex; ASCOR (TN); SCHEMBL785; bmse000182; SCHEMBL4430; L-Ascorbic acid, FCC, FG; BSPBio_000329; (r)-5-(1,2-dihydroxy-ethyl)-3,4-dihydroxy-5h-furan-2-one; MLS002153776; CHEMBL40274; BPBio1_000363; GTPL4532; GTPL4781; INS NO.300; L-Ascorbic acid, reagent grade; DTXSID5020106; L-Ascorbic acid, >=99.0%; DTXSID50986567; INS-300; Ascorbic acid (JP17/USP/INN); HMS2096A11; HMS2231N16; HMS3713A11; L-Ascorbic acid ACS reagent grade; (2R)-2-[(1S)-1,2-Dihydroxyethyl]-4,5-dihydroxy-furan-3-one; BCP27915; HY-B0166; Tox21_110315; Tox21_112104; Tox21_202127; Tox21_302958; ANW-73969; gamma-lactone L-threo-Hex-2-enonate; L-Ascorbic acid, analytical standard; L-Ascorbic acid, AR, >=99.5%; s3114; AKOS016843589; Tox21_112104_1; ZINC100006770; ZINC100019304; CCG-207946; DB00126; L-Ascorbic acid, mixt. with vitamin B; NSC 218455; gamma-lactone L-threo-Hex-2-enonic acid; L-Ascorbic acid, ACS reagent, >=99%; NCGC00091517-01; NCGC00091517-02; NCGC00091517-03; NCGC00091517-06; NCGC00188972-01; NCGC00256504-01; NCGC00259676-01; 53262-66-1; BP-12831; SMR001233160; L-Ascorbic acid, plant cell culture tested; AB0010512; L-Ascorbic acid, reagent grade, crystalline; A0537; A8158; AB00376923; Ascorbic Acid (L-Ascorbic Acid; Vitamin C); SW198791-2; L-Ascorbic acid, BioUltra, >=99.5% (RT); L-Ascorbic acid, tested according to Ph.Eur.; 3466-EP2269610A2; 3466-EP2269978A2; 3466-EP2269985A2; 3466-EP2269988A2; 3466-EP2269991A2; 3466-EP2270000A1; 3466-EP2270002A1; 3466-EP2270008A1; 3466-EP2270011A1; 3466-EP2270505A1; 3466-EP2272516A2; 3466-EP2272537A2; 3466-EP2272822A1; 3466-EP2272834A1; 3466-EP2272835A1; 3466-EP2272844A1; 3466-EP2275413A1; 3466-EP2277848A1; 3466-EP2277865A1; 3466-EP2281823A2; 3466-EP2284149A1; 3466-EP2284150A2; 3466-EP2284151A2; 3466-EP2284152A2; 3466-EP2284153A2; 3466-EP2284155A2; 3466-EP2284156A2; 3466-EP2284164A2; 3466-EP2284171A1; 3466-EP2284178A2; 3466-EP2284179A2; 3466-EP2287140A2; 3466-EP2287148A2; 3466-EP2287150A2; 3466-EP2287153A1; 3466-EP2287156A1; 3466-EP2289510A1; 3466-EP2289883A1; 3466-EP2289890A1; 3466-EP2289892A1; 3466-EP2292227A2; 3466-EP2292228A1; 3466-EP2292592A1; 3466-EP2292612A2; 3466-EP2292617A1; 3466-EP2295055A2; 3466-EP2295401A2; 3466-EP2295409A1; 3466-EP2295416A2; 3466-EP2295419A2; 3466-EP2295426A1; 3466-EP2295427A1; 3466-EP2295435A1; 3466-EP2298735A1; 3466-EP2298742A1; 3466-EP2298748A2; 3466-EP2298768A1; 3466-EP2298770A1; 3466-EP2298776A1; 3466-EP2301536A1; 3466-EP2301538A1; 3466-EP2301929A1; 3466-EP2301931A1; 3466-EP2301935A1; 3466-EP2301940A1; 3466-EP2305219A1; 3466-EP2305257A1; 3466-EP2305636A1; 3466-EP2305637A2; 3466-EP2305648A1; 3466-EP2305651A1; 3466-EP2305668A1; 3466-EP2305674A1; 3466-EP2305679A1; 3466-EP2305683A1; 3466-EP2308854A1; 3466-EP2308857A1; 3466-EP2308861A1; 3466-EP2308867A2; 3466-EP2308870A2; 3466-EP2311453A1; 3466-EP2311455A1; 3466-EP2311805A1; 3466-EP2311807A1; 3466-EP2311809A1; 3466-EP2311824A1; 3466-EP2311839A1; 3466-EP2311842A2; 3466-EP2314295A1; 3466-EP2314584A1; 3466-EP2314585A1; 3466-EP2314588A1; 3466-EP2314589A1; 3466-EP2314590A1; 3466-EP2314593A1; 3466-EP2316452A1; 3466-EP2316457A1; 3466-EP2316458A1; 3466-EP2316470A2; 3466-EP2316825A1; 3466-EP2316826A1; 3466-EP2316827A1; 3466-EP2316828A1; 3466-EP2316832A1; 3466-EP2316833A1; 3466-EP2316837A1; 3466-EP2374792A1; 3466-EP2377510A1; 3466-EP2380568A1; C 1000; C00072; D00018; L-Ascorbic acid, p.a., ACS reagent, 99.0%; 93398-EP2380568A1; AB00376923_04; AB00376923_05; L-Ascorbic acid 1000 microg/mL in Acetonitrile; L-Ascorbic acid, JIS special grade, >=99.0%; L-Ascorbic acid, Vetec(TM) reagent grade, 99%; L-Ascorbic acid, BioXtra, >=99.0%, crystalline; Q199678; L-Ascorbic acid, puriss. p.a., >=99.0% (RT); Q27101942; 47A605F0-4187-47A8-B0CE-F9E7DA1B0076; L-Ascorbic acid, p.a., ACS reagent, reag. ISO, 99.7%; Ascorbic acid, British Pharmacopoeia (BP) Reference Standard; Ascorbic acid, European Pharmacopoeia (EP) Reference Standard; L-Ascorbic acid, certified reference material, TraceCERT(R); L-Ascorbic acid, powder, cell culture tested, gamma-irradiated; 3,4-Dihydroxy-5beta-[(S)-1,2-dihydroxyethyl]furan-2(5H)-one; Ascorbic acid, United States Pharmacopeia (USP) Reference Standard; (2R)-2-[(1S)-1,2-dihydroxyethyl]-4,5-dihydroxy-2,3-dihydrofuran-3-one; 4-((E)-2-[(2-HYDROXYETHYL)SULFANYL]DIAZENYL)BENZENECARBOXYLICACID; (5R)-5-[(1S)-1,2-dihydroxyethyl]-3,4-dihydroxyfuran-2(5H)-one (non-preferred name); L-Ascorbic acid solution, 1.0 mg/mL in acetonitrile: water, certified reference material; L-Ascorbic acid, anhydrous, free-flowing, Redi-Dri(TM), ACS reagent, >=99%; L-Ascorbic acid, suitable for cell culture, suitable for plant cell culture, >=98%; L-Ascorbic Acid (Vitamin C)-13C6 solution, 500 mug/mL in acetonitrile: water, certified reference material, ampule of 1 mL; L-Ascorbic acid, puriss. p.a., ACS reagent, reag. ISO, reag. Ph. Eur., 99.7-100.5% (oxidimetric); Valeryl fentanyl hydrochloride solution, 100 mug/mL in methanol (as a free base), certified reference material, ampule of 0.5 mL
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Species Origin Actinidia chinensis ...     Click to Show/Hide
Actinidia chinensis
Kingdom: Viridiplantae
Phylum: Streptophyta
Class: Magnoliopsida
Order: Ericales
Family: Actinidiaceae
Genus: Actinidia
Species: Actinidia chinensis
Disease Vitamin deficiency [ICD-11: 5B55-5B5F] Approved [1]
Structure
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2D MOL

3D MOL

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Formula
C6H8O6
PubChem CID
54670067
Canonical SMILES
C(C(C1C(=C(C(=O)O1)O)O)O)O
InChI
1S/C6H8O6/c7-1-2(8)5-3(9)4(10)6(11)12-5/h2,5,7-10H,1H2/t2-,5+/m0/s1
InChIKey
CIWBSHSKHKDKBQ-JLAZNSOCSA-N
CAS Number
CAS 50-81-7
ChEBI ID
CHEBI:29073
Herb ID
HBIN048047
SymMap ID
SMIT00118
TCMSP ID
MOL001691
TTD Drug ID
D07AHW
Combinatorial Therapeutic Effect(s) Validated Clinically or Experimentally
    α. A List of Drug(s) Whose Efficacy can be Enhanced by This NP
          Cisplatin      Bladder cancer     Click to Show/Hide the Molecular Data of This Drug
                 Achieving Therapeutic Synergy     Click to Show/Hide
                    Representative Experiment Reporting the Effect of This Combination [2]
                    Detail(s)  Combination Info  click to show the detail info of this combination
                    Experimental
                    Result(s)		 Ascorbic acid renders cisplatin more effective as an antitumor agent.
    β. A List of Drug(s) Whose Adverse Effect can be Decreased by This NP
          S-adenosylmethionine      Hepatic fibrosis/cirrhosis     Click to Show/Hide the Molecular Data of This Drug
                 Decreasing Adverse Drug Reaction     Click to Show/Hide
                    Representative Experiment Reporting the Effect of This Combination [3]
                    Detail(s)  Combination Info  click to show the detail info of this combination
                    In-vivo Model Male C57BL/6 mice between 8-10 weeks were injected with DMSO, 15 mg/kg doxorubicin, or doxorubicin plus 25 mg/kg visnagin or 10 mg/kg diphenylurea intraperitoneally (n=4-5 each).
                    Experimental
                    Result(s)		 There are synergistic antioxidative effects among the antioxidants, SAMe and vitamins C and E, that protect the liver from TAA-induced HDIR, suggesting that antioxidant treatment may best be done using a balanced "cocktail.".
          Diazinon + Ceftriaxone     Click to Show/Hide the Molecular Data of This Drug
                 Decreasing Adverse Drug Reaction     Click to Show/Hide
                    Representative Experiment Reporting the Effect of This Combination [4]
                    Detail(s)  Combination Info  click to show the detail info of this combination
                    Molecule(s)
                    Regulation		 Down-regulation Expression TNF  Molecule Info 
Pathway MAP
                    In-vivo Model Male Wistar rats, weighing 175 +/- 25 g were used in this study.
                    Experimental
                    Result(s)		 Ceftriaxone and/or vitamin C administration are able to minimize the toxic effects of DZN by its free radical-scavenging and potent antioxidant activity.
Target and Pathway
Target(s) Collagen (CO)  Molecule Info  [5]
Sodium-dependent vitamin C transporter 1 (SVCT1)  Molecule Info  [6]
Sodium-dependent vitamin C transporter 2 (SVCT2)  Molecule Info  [7]
References
Reference 1 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 4781).
Reference 2 Chemo-immunotherapeutical studies on Dalton's lymphoma in mice using cisplatin and ascorbic acid: synergistic antitumor effect in vivo and in vitro. Arch Immunol Ther Exp (Warsz). 1993;41(5-6):327-33.
Reference 3 Synergistic protection by S-adenosylmethionine with vitamins C and E on liver injury induced by thioacetamide in rats. Free Radic Biol Med. 2006 Feb 15;40(4):617-24.
Reference 4 Synergistic protective role of ceftriaxone and ascorbic acid against subacute diazinon-induced nephrotoxicity in rats. Cytotechnology. 2016 Mar;68(2):279-89.
Reference 5 Effects of vitamin C on dark circles of the lower eyelids: quantitative evaluation using image analysis and echogram. Skin Res Technol. 2009 May;15(2):214-7.
Reference 6 Decreased expression of the vitamin C transporter SVCT1 by ascorbic acid in a human intestinal epithelial cell line. Br J Nutr. 2002 Feb;87(2):97-100.
Reference 7 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 1042).
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