Drug Combination Details
| General Information of the Combination (ID: C87415) | |||||
|---|---|---|---|---|---|
| Name | Vitamin C | + | Diazinon + Ceftriaxone | ||
| Click to Show/Hide the Each NP or Drug Information of This Combination | |||||
| Name | Vitamin C NP Info | Drug Info | |||
| Structure |
|
|
|||
| Name | Drug Info | ||||
| Structure |
|
|
|||
| Disease |
Healthy individual
[ICD-11: N.A.]
|
Investigative | [1] | ||
| Combinatorial Therapeutic Effect(s) Validated Clinically or Experimentally | ||||||
|---|---|---|---|---|---|---|
| α. Decreasing Adverse Drug Reaction by This Combination | ||||||
| Decreasing Adverse Drug Reaction | Click to Show/Hide | |||||
| Experiment 1 Reporting the Effect of This Combination | [1] | |||||
| Molecule(s)
Regulation |
Down-regulation | Expression | TNF | Molecule Info |
Pathway MAP
|
|
| In-vivo Model | Male Wistar rats, weighing 175 +/- 25 g were used in this study. | |||||
| Experimental
Result(s) |
Ceftriaxone and/or vitamin C administration are able to minimize the toxic effects of DZN by its free radical-scavenging and potent antioxidant activity. | |||||
| References | ||||
|---|---|---|---|---|
| Reference 1 | Synergistic protective role of ceftriaxone and ascorbic acid against subacute diazinon-induced nephrotoxicity in rats. Cytotechnology. 2016 Mar;68(2):279-89. | |||
