Drug Details

General Information of the Drug (ID: DR2276)
Name
Diazinon
Synonyms
diazinon; Dimpylate; 333-41-5; Diazinone; Oleodiazinon; Neocidol; Ciazinon; Dassitox; Diazitol; Ektoband; Nedcidol; Spectracide; Antigal; Basudin; Bazuden; Dacutox; Dazzel; Diazide; Diazol; Exodin; Flytrol; Galesan; Nucidol; Sarolex; Dicid; Alfa-tox; Diazajet; Dimpylat; Garden Tox; Neocidol (oil); Bassadinon; Terminator; Compass; Disonex; Dizinon; Drawizon; Kayazinon; Kayazol; Meodinon; Dyzol; Nipsan; Diazinon ag 500; Knox-out; Delzinon; Dimpylatum; Dipofene; Dizictol; Neodinon; Optimizer; Bazudin; Dizinil; Srolex; Basudin 10 G; Geigy 24480; Basudin S; Knox Out 2FM; Diagran; Fezudin; NCI-C08673; AG-500; ENT 19,507; Isopropylmethylpyrimidyl diethyl thiophosphate; G-24480; Diziktol; O,O-Diethyl 2-isopropyl-4-methylpyrimidyl-6-thiophosphate; G 301; O,O-Diethyl O-(2-isopropyl-6-methyl-4-pyrimidinyl) phosphorothioate; UNII-YUS1M1Q929; 4-Pyrimidinol, 2-isopropyl-6-methyl-, O-ester with O,O-diethyl phosphorothioate; Diethyl 4-(2-isopropyl-6-methylpyrimidinyl)phosphorothionate; O-2-Isopropyl-4-methylpyrimidyl-O,O-diethyl phosphorothioate; O,O-Diethyl O-(2-isopropyl-4-methyl-6-pyrimidyl) thionophosphate; CHEBI:34682; O,O-Diethyl O-6-methyl-2-isopropyl-4-pyrimidinyl phosphorothioate; Phosphorothioate, O,O-diethyl O-6-(2-isopropyl-4-methylpyrimidyl); Thiophosphate de O,O-diethyle et de O-2-isopropyl-4-methyl-6-pyrimidyle; Phosphorothioic acid, O,O-diethyl O-(6-methyl-2-(1-methylethyl)-4-pyrimidinyl) ester; YUS1M1Q929; Diethyl 2-isopropyl-4-methyl-6-pyrimidinyl phosphorothionate; NSC8938; O,O-Diethyl-O-(2-isopropyl-4-methyl-pyrimidin-6-yl)-monothiofosfaat; Phosphorothioic acid, O,O-diethyl O-(2-isopropyl-6-methyl-4-pyrimidinyl) ester; Diethyl 2-isopropyl-4-methyl-6-pyrimidyl thionophosphate; NCGC00091073-01; Bazudine; Neotsidol; O,O-Diethyl 2-isopropyl-6-methyl-4-pyrimidinylphosphorothioate; DSSTox_CID_407; O,O-Diethyl O-(2-isopropyl-4-methyl-6-pyrimidinyl) phosphorothioate; O,O-diethyl O-[6-methyl-2-(1-methylethyl)pyrimidin-4-yl] thiophosphate; Kleen-Dok; DSSTox_RID_75567; Phosphorothioic acid, O,O-diethyl O-[6-methyl-2-(1-methylethyl)-4-pyrimidinyl] ester; DSSTox_GSID_20407; Diazinon, analytical standard; KFM Blowfly Dressing; Compass (insecticide); Caswell No. 342; gardentox; Dimpilato; Diaterr-fos; Dimpylatum [INN-Latin]; O,O-Diaethyl-O-(2-isopropyl-4-methyl-pyrinidin-6-yl)-monothiophosphat; O,O-Diethyl O-(2-isopropyl-4-methyl-6-pyrimidyl) phosphorothioate; Cooper's Flystrike Powder; Dimpilato [INN-Spanish]; NSC 8938; Phosphorothioic acid, O,O-diethylO-[6-methyl-2-(1-methylethyl)-4-pyrimidinyl] ester; Diazinon [ANSI:BSI:ISO]; CAS-333-41-5; CCRIS 204; HSDB 303; Knox Out Yellow Jacket Contorl; OMS 469; EINECS 206-373-8; PT 265; EPA Pesticide Chemical Code 057801; BRN 0273790; Spertacide; Bazanon; Antlak; AI3-19507; Root guard; Diethyl dimpylatum; diethoxy-(6-methyl-2-propan-2-ylpyrimidin-4-yl)oxy-sulfanylidene-?^{5}-phosphane; Dimpylate, INN; Basudin 5G; Dimpylate (INN); Spectracide 25EC; G 24480; Agridin 60; Basudin 10G; Spectrum_001777; Dimpylate [INN:BAN]; New Z Diazinon (TN); SpecPlus_000344; O,O-Diethyl O-(2-isopropyl-6-methyl-4-pyrimidinyl)phosphorothioate; O,O-Diethyl-O-(2-isopropyl-4-methyl-6-pyrimidyl)phosphorothioate; Spectrum2_001226; Spectrum3_000802; Spectrum4_000642; Spectrum5_001929; Thiophosphoric acid 2-isopropyl-4-methyl-6-pyrimidyl diethyl ester; O,O-Diethyl-O-(2-isopropyl-4-methyl-6-pyrimidinyl)-phosphorothioate; Phosphorothioic acid, O,O-diethyl O-(isopropylmethylpyrimidinyl) ester; O,O-Diaethyl-O-(2-isopropyl-4-methyl)-6-pyrimidyl-thionophosphat [German]; O,O-Diaethyl-O-(2-isopropyl-4-methyl-pyrimidin-6-yl)-monothiophosphat [German]; O,O-Diethyl O-(6-methyl-2-(1-methylethyl)-4-pyrimidinyl)phosphorothioate; O,O-Diethyl-O-(2-isopropyl-4-methyl-pyrimidin-6-yl)-monothiofosfaat [Dutch]; O,O-Dietil-O-(2-isopropil-4-metil-pirimidin-6-il)-monotiofosfato [Italian]; Optimizer Insecticide (TN); Thiophosphate de O,O-diethyle et de O-2-isopropyl-4-methyl-6-pyrimidyle [French]; SCHEMBL17453; BSPBio_002263; KBioGR_000983; KBioSS_002258; 5-23-11-00187 (Beilstein Handbook Reference); MLS002207243; BIDD:ER0457; DivK1c_006440; SPBio_001072; CHEMBL388560; ZINC1309; DIAZINON (DIETHYL-D10); DTXSID9020407; FHIVAFMUCKRCQO-UHFFFAOYSA-; KBio1_001384; KBio2_002257; KBio2_004825; KBio2_007393; KBio3_001763; AMY3613; HMS3264I04; Pharmakon1600-00330017; EBD29972; HY-B1113; NSC-8938; O,O-Diaethyl-O-(2-isopropyl-4-methyl)-6-pyrimidyl-thionophosphat; o,o-diethyl o-2-isopropyl-6-methylpyrimidin-4-yl phosphorothioate; Diazinon 100 microg/mL in Acetone; Tox21_111077; Tox21_201409; Tox21_300730; BDBM50005409; CCG-39143; ENT 19507; NSC755893; O,O-Diaethyl-O-(2-isopropyl-4-methyl-pyrimidin-6-yl)-monothiophosphat; O,O-Dietil-O-(2-isopropil-4-metil-pirimidin-6-il)-monotiofosfato; Diazinon 10 microg/mL in Cyclohexane; Diazinon 1000 microg/mL in Toluene; AKOS025311513; Diazinon 1000 microg/mL in Methanol; diethoxy-(2-isopropyl-6-methyl-pyrimidin-4-yl)oxy-thioxo-$l^{5}-phosphane; O,O-diethyl O-[6-methyl-2-(propan-2-yl)pyrimidin-4-yl] phosphorothioate; Tox21_111077_1; CS-4712; Diazinon 10 microg/mL in Acetonitrile; Diazinon 100 microg/mL in Cyclohexane; NSC-755893; Diazinon 100 microg/mL in Acetonitrile; NCGC00091073-02; NCGC00091073-03; NCGC00091073-04; NCGC00091073-05; NCGC00091073-06; NCGC00091073-07; NCGC00254636-01; NCGC00258960-01; SMR000777921; SBI-0052498.P002; DB-048387; Diazinon, PESTANAL(R), analytical standard; FT-0603088; FT-0778116; C14324; D07856; AB00053004_04; 333D415; Q411202; SR-01000872734; Q-200952; SR-01000872734-1; BRD-K60567437-001-04-5; Diazinon, certified reference material, TraceCERT(R); 4-Pyrimidinol, O-ester with O,O-diethyl phosphorothioate; WLN: T6N CNJ BY1 & 1 DOPS & O2 & O2 F1; O, O-Diethyl 2-isopropyl-4-methylpyrimidyl-6-thiophosphate; O,O-Diethyl-O-(2-isopropyl-4-methylpyrimidyl)thiophosphate; o,o-Dietil-o-(2-isopropil-4-metil-pirimidin-il)-monotiofosato; Phosphorothioate,O-diethyl O-6-(2-isopropyl-4-methylpyrimidyl); O,O-Diethyl O-(2-isopropyl-6-methyl-4-primidinyl)phosphorothioate; O,O-Diethyl O-(2-isopropyl-6-methyl-4-pyrimidinyl) thiophosphate; O,O-Diethyl o-(2-isopropyl-6-methyl-4-pyrimidinyl) thiophosphate #; O,O-diethyl O-(2-isopropyl-6-methyl-4-pyrimidinyl)thio-phosphate; O,O-Diethyl-O-(2-isopropyl-4-methyl-6-pyrimidyl) thiophosphate; diethoxy-(6-methyl-2-propan-2-ylpyrimidin-4-yl)oxy-sulfanylidenephosphorane; o,o-Diethyl-O-(6-methyl-2-(1-methylethyl)-4-pyrimidinyl)phosophorothioate; Phosphorothioic acid, O,O-diethyl 2-isopropyl-6-methyl-4-pyrimidinyl ester; Phosphorothioic acid,O-diethyl O-(2-isopropyl-6-methyl-4-pyrimidinyl) ester; Diazinon solution, 100 mug/mL in acetonitrile, PESTANAL(R), analytical standard; diethoxy-(6-methyl-2-propan-2-ylpyrimidin-4-yl)oxy-sulfanylidene-$l^{5-phosphane; ethyl 6-methyl-2-(propan-2-yl)pyrimidin-4-yl ethoxy(sulfanylidene)phosphonite; Phosphorothioic acid, O,O-diethyl {O-[6-methyl-2-(1-methylethyl)-4-pyrimidinyl]} ester; PHOSPHOROTHIOIC ACID,O-DIETHYL O-[6-METHYL-2-(1-METHYLETHYL)-4-PYRIMIDINYL] ESTER; O,O-Diethyl O-2-isopropyl-4-methyl-6-pyrimidyl thiophosphate; O,O-Diethyl O-(6-methyl-2-(1-methylethyl)-4-pyrimidinyl) phosophorothioate
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Molecular Type
Small molecule
Disease Scabies [ICD-11: 1G04] Investigative [1]
Structure
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2D MOL

3D MOL

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Formula
C12H21N2O3PS
PubChem CID
3017
Canonical SMILES
CCOP(=S)(OCC)OC1=NC(=NC(=C1)C)C(C)C
InChI
1S/C12H21N2O3PS/c1-6-15-18(19,16-7-2)17-11-8-10(5)13-12(14-11)9(3)4/h8-9H,6-7H2,1-5H3
InChIKey
FHIVAFMUCKRCQO-UHFFFAOYSA-N
CAS Number
CAS 333-41-5
ChEBI ID
CHEBI:34682
Combinatorial Therapeutic Effect(s) Validated Clinically or Experimentally
    α. A List of Natural Product(s) Able to Decrease the Adverse Effect of This Drug
          Vitamin C      Actinidia chinensis     Click to Show/Hide the Molecular Data of This NP
                 Decreasing Adverse Drug Reaction     Click to Show/Hide
                    Representative Experiment Reporting the Effect of This Combination [2]
                    Detail(s)  Combination Info  click to show the detail info of this combination
                    Molecule(s)
                    Regulation		 Down-regulation Expression TNF  Molecule Info 
Pathway MAP
                    In-vivo Model Male Wistar rats, weighing 175 +/- 25 g were used in this study.
                    Experimental
                    Result(s)		 Ceftriaxone and/or vitamin C administration are able to minimize the toxic effects of DZN by its free radical-scavenging and potent antioxidant activity.
Target and Pathway
Target(s) Nuclear factor erythroid 2-related factor 2 (Nrf2)  Molecule Info  [3]
KEGG Pathway Protein processing in endoplasmic reticulum Click to Show/Hide
NetPath Pathway IL5 Signaling Pathway Click to Show/Hide
WikiPathways Oxidative Stress Click to Show/Hide
2 Transcriptional activation by NRF2
3 NRF2 pathway
4 Nuclear Receptors Meta-Pathway
5 Aryl Hydrocarbon Receptor Pathway
6 Mesodermal Commitment Pathway
7 Aryl Hydrocarbon Receptor
8 Quercetin and Nf-kB/ AP-1 Induced Cell Apoptosis
9 Arylhydrocarbon receptor (AhR) signaling pathway
References
Reference 1 Diazinon for control of sheep scab. Vet Rec. 2020 Feb 29;186(8):254-255.
Reference 2 Synergistic protective role of ceftriaxone and ascorbic acid against subacute diazinon-induced nephrotoxicity in rats. Cytotechnology. 2016 Mar;68(2):279-89.
Reference 3 Thearubigin regulates the production of Nrf2 and alleviates LPS-induced acute lung injury in neonatal rats. 3 Biotech. 2019 Dec;9(12):451.
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