Molecule Details

Natural Product(s) of This Target
1 Brusatol  NP Info  Investigative Brucea javanica
2 Cucurbitacin I  NP Info  Investigative Citrullus lanatus
3 Danggui Buxue Tang  NP Info  . Not Available
4 Daphnetin  NP Info  Investigative Euphorbia
5 Ginsenoside Rh2  NP Info  Investigative Panax ginseng
6 Isoliquiritigenin  NP Info  Investigative Robinia pseudoacacia
7 Lycopene  NP Info  Phase 2 Daucus carota
8 N-containing chalcone derivative  NP Info  . Not Available
9 Neferine  NP Info  Investigative Nelumbo nucifera
10 Oridonin  NP Info  Investigative Isodon rubescens
11 Polydatin  NP Info  Investigative Polygonum cuspidatum
12 Salvianolic acid A  NP Info  Investigative Salvia
13 Xanthohumol  NP Info  Investigative Humulus lupulus
Drug(s) of This Target
1 Cisplatin  Drug Info  Approved Bladder cancer
2 Diazinon  Drug Info  Investigative Scabies
3 Doxorubicin  Drug Info  Approved Solid tumour/cancer
4 MST312  Drug Info  Investigative Lung cancer
References
Reference 1 Free heme regulates placenta growth factor through NRF2-antioxidant response signaling. Free Radic Biol Med. 2019 Nov 1;143:300-308.
Reference 2 Low nanomolar concentrations of Cucurbitacin-I induces G2/M phase arrest and apoptosis by perturbing redox homeostasis in gastric cancer cells in vitro and in vivo. Cell Death Dis. 2016 Feb 18;7(2):e2106.
Reference 3 Daphnetin-mediated Nrf2 antioxidant signaling pathways ameliorate tert-butyl hydroperoxide (t-BHP)-induced mitochondrial dysfunction and cell death. Free Radic Biol Med. 2017 May;106:38-52.
Reference 4 Calycosin suppresses expression of pro-inflammatory cytokines via the activation of p62/Nrf2-linked heme oxygenase 1 in rheumatoid arthritis synovial fibroblasts. Pharmacol Res. 2016 Nov;113(Pt A):695-704.
Reference 5 Isoliquiritigenin alleviates early brain injury after experimental intracerebral hemorrhage via suppressing ROS- and/or NF-KappaB-mediated NLRP3 inflammasome activation by promoting Nrf2 antioxidant pathway. J Neuroinflammation. 2017 Jun 13;14(1):119.
Reference 6 Natural ingredients-derived antioxidants attenuate H(2)O(2)-induced oxidative stress and have chondroprotective effects on human osteoarthritic chondrocytes via Keap1/Nrf2 pathway. Free Radic Biol Med. 2020 May 20;152:854-864.
Reference 7 Mitochondrial protective effect of neferine through the modulation of nuclear factor erythroid 2-related factor 2 signalling in ischaemic stroke. Br J Pharmacol. 2019 Feb;176(3):400-415.
Reference 8 Oridonin protects LPS-induced acute lung injury by modulating Nrf2-mediated oxidative stress and Nrf2-independent NLRP3 and NF-KappaB pathways. Cell Commun Signal. 2019 Jun 11;17(1):62.
Reference 9 Polydatin prevents fructose-induced liver inflammation and lipid deposition through increasing miR-200a to regulate Keap1/Nrf2 pathway. Redox Biol. 2018 Sep;18:124-137.
Reference 10 Salvianolic acid A protects RPE cells against oxidative stress through activation of Nrf2/HO-1 signaling. Free Radic Biol Med. 2014 Apr;69:219-28.
Reference 11 Activated AMPK boosts the Nrf2/HO-1 signaling axis--A role for the unfolded protein response. Free Radic Biol Med. 2015 Nov;88(Pt B):417-426.
Reference 12 Thearubigin regulates the production of Nrf2 and alleviates LPS-induced acute lung injury in neonatal rats. 3 Biotech. 2019 Dec;9(12):451.
Reference 13 Fernblock? Upregulates NRF2 Antioxidant Pathway and Protects Keratinocytes from PM(2.5)-Induced Xenotoxic Stress. Oxid Med Cell Longev. 2020 Apr 14;2020:2908108.