Drug Details

General Information of the Drug (ID: DR6422)
Name
MST312
Synonyms
Telomerase Inhibitor IX; 368449-04-1; CHEMBL2170856; N-[3-[(2,3-dihydroxybenzoyl)amino]phenyl]-2,3-dihydroxybenzamide; N-[3-[[(2,3-dihydroxyphenyl)-oxomethyl]amino]phenyl]-2,3-dihydroxybenzamide; Benzamide, N,N'-1,3-phenylenebis[2,3-dihydroxy-; MST312; SCHEMBL17005794; CHEBI:95003; DTXSID90439103; ZINC3937611; BDBM50396097; MST-312, >=98% (HPLC); BRD-K19894101-001-01-6; Q27166764
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Molecular Type
Small molecule
Disease Lung cancer [ICD-11: 2C25] Investigative [1]
Structure
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2D MOL

3D MOL

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Formula
C20H16N2O6
PubChem CID
10385095
Canonical SMILES
C1=CC(=CC(=C1)NC(=O)C2=C(C(=CC=C2)O)O)NC(=O)C3=C(C(=CC=C3)O)O
InChI
1S/C20H16N2O6/c23-15-8-2-6-13(17(15)25)19(27)21-11-4-1-5-12(10-11)22-20(28)14-7-3-9-16(24)18(14)26/h1-10,23-26H,(H,21,27)(H,22,28)
InChIKey
MIQUEZGHEJGPJB-UHFFFAOYSA-N
CAS Number
CAS 368449-04-1
GDSC
MST312
Combinatorial Therapeutic Effect(s) Validated Clinically or Experimentally
    α. A List of Natural Product(s) Able to Enhance the Efficacy of This Drug
          Morin      Morus serrata     Click to Show/Hide the Molecular Data of This NP
                 Augmenting Drug Sensitivity     Click to Show/Hide
                    Representative Experiment Reporting the Effect of This Combination [2]
                    Detail(s)  Combination Info  click to show the detail info of this combination
                    Molecule(s)
                    Regulation		 Down-regulation Phosphorylation STAT3  Molecule Info 
Pathway MAP
                    In-vitro Model HT-29 CVCL_0320 Colon adenocarcinoma Homo sapiens
SW620 CVCL_0547 Colon adenocarcinoma Homo sapiens
MDA-MB-231 CVCL_0062 Breast adenocarcinoma Homo sapiens
                    Experimental
                    Result(s)		 Combination treatment with morin and telomerase inhibitor MST-312 reduces cancer stem cell traits by targeting STAT3 and telomerase.
Target and Pathway
Target(s) Nuclear factor erythroid 2-related factor 2 (Nrf2)  Molecule Info  [3]
KEGG Pathway Protein processing in endoplasmic reticulum Click to Show/Hide
NetPath Pathway IL5 Signaling Pathway Click to Show/Hide
WikiPathways Oxidative Stress Click to Show/Hide
2 Transcriptional activation by NRF2
3 NRF2 pathway
4 Nuclear Receptors Meta-Pathway
5 Aryl Hydrocarbon Receptor Pathway
6 Mesodermal Commitment Pathway
7 Aryl Hydrocarbon Receptor
8 Quercetin and Nf-kB/ AP-1 Induced Cell Apoptosis
9 Arylhydrocarbon receptor (AhR) signaling pathway
References
Reference 1 Inhibition of telomerase activity preferentially targets aldehyde dehydrogenase-positive cancer stem-like cells in lung cancer. Mol Cancer. 2011 Aug 9;10:96.
Reference 2 Combination treatment with flavonoid morin and telomerase inhibitor MST?312 reduces cancer stem cell traits by targeting STAT3 and telomerase. Int J Oncol. 2016 Aug;49(2):487-98.
Reference 3 Fernblock? Upregulates NRF2 Antioxidant Pathway and Protects Keratinocytes from PM(2.5)-Induced Xenotoxic Stress. Oxid Med Cell Longev. 2020 Apr 14;2020:2908108.
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