Drug Combination Details
| General Information of the Combination (ID: C74471) | |||||
|---|---|---|---|---|---|
| Name | Flavopiridol NP Info | + | Vorinostat Drug Info | ||
| Structure |
|
+ |
|
||
| Disease |
Acute myeloid leukemia
[ICD-11: 2A60]
|
Phase 1 | [1] | ||
|
Chronic myelogenous leukaemia
[ICD-11: 2A20]
|
Phase 1 | [1] | |||
|
Anemia
[ICD-11: 3A9Z]
|
Phase 1 | [1] | |||
|
Solid tumour/cancer
[ICD-11: 2A00-2F9Z]
|
Phase 1 | [2] | |||
|
Adrenocortical carcinoma
[ICD-11: 2D11]
|
Investigative | [3] | |||
| Click to Show/Hide the Whole Disease Information of This Combination | |||||
| Combinatorial Therapeutic Effect(s) Validated Clinically or Experimentally | ||||||
|---|---|---|---|---|---|---|
| α. Enhancing Drug Efficacy by This Combination | ||||||
| Achieving Therapeutic Synergy | Click to Show/Hide | |||||
| Experiment 1 Reporting the Effect of This Combination | [3] | |||||
| Molecule(s)
Regulation |
Down-regulation | Expression | CCNB1 | Molecule Info |
Pathway MAP
|
|
| Down-regulation | Expression | MAD2L1 | Molecule Info |
Pathway MAP
|
||
| Down-regulation | Expression | MMP-2 | Molecule Info |
Pathway MAP
|
||
| In-vitro Model | CHLA-15 | CVCL_6594 | Neuroblastoma | Homo sapiens | ||
| CHLA-20 | CVCL_6602 | Neuroblastoma | Homo sapiens | |||
| SK-N-BE(1) | CVCL_9898 | Neuroblastoma | Homo sapiens | |||
| SK-N-RA | CVCL_AQ53 | Neuroblastoma | Homo sapiens | |||
| LA-N-6 | CVCL_1363 | Neuroblastoma | Homo sapiens | |||
| CHLA-136 | CVCL_6590 | Neuroblastoma | Homo sapiens | |||
| CHLA-79 | CVCL_6608 | Neuroblastoma | Homo sapiens | |||
| CHLA-119 | CVCL_A055 | Neuroblastoma | Homo sapiens | |||
| CHLA-90 | CVCL_6610 | Neuroblastoma | Homo sapiens | |||
| CHLA-172 | CVCL_A056 | Neuroblastoma | Homo sapiens | |||
| Experimental
Result(s) |
Combination of vorinostat and flavopiridol is selectively cytotoxic to multidrug-resistant neuroblastoma cell lines with mutant TP53. The combination caused reduction in the expression of G(2)/M proteins (cyclin B1, Mad2, MPM2) in 2 cell lines with mt TP53 but not in those with wt TP53. | |||||
