Drug Combination Details

General Information of the Combination (ID: C74541)
Name Febrifugine   NP Info  + Chloroquine   Drug Info 
Structure +
Disease
Malaria [ICD-11: 1F40]
Investigative [1]
Combinatorial Therapeutic Effect(s) Validated Clinically or Experimentally
    α. Enhancing Drug Efficacy by This Combination
                 Achieving Therapeutic Synergy     Click to Show/Hide
                    Experiment 1 Reporting the Effect of This Combination [1]
                    In-vivo Model Mice were infected intraperitoneally with parasitized erythro-cytes.
                    Experimental
                    Result(s)		 Malaria parasites in the mice given chloroquine plus alkaloids decreased on day 6 and then were not detected by a microscopic examination during observation period.
References
Reference 1 Combination effects of chloroquine with the febrifugine and isofebrifugine mixture against a blood-induced infection with chloroquine-resistant Plasmodium berghei NK65 in ICR mice. Phytother Res. 2003 Dec;17(10):1234-6.
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