Natural Product (NP) Details
| General Information of the NP (ID: NP8223) | |||||
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| Name |
Febrifugine
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| Synonyms |
Febrifugine; 24159-07-7; UNII-89UWD0FH2I; 89UWD0FH2I; Ferbifrugin; Dichroin; beta-Dichroine; 3-(3-(3-Hydroxy-2-piperidinyl)-2-oxopropyl)-4(3H)-quinazolinone; 3-[3-[(2R,3S)-3-Hydroxy-2-piperidinyl]-2-oxopropyl]-4(3H)-quinazolinone; 3-{3-[(2R,3S)-3-hydroxypiperidin-2-yl]-2-oxopropyl}quinazolin-4(3H)-one; Febrifugine;; NSC 315535; Febrifugine (8CI); 3-[3-[3(S)-Hydroxypiperidin-2(R)-yl]-2-oxopropyl]-3,4-dihydroquinazolin-4-one; CHEMBL322782; SCHEMBL9542831; HY-N2384; ZINC5641945; MFCD11867855; CS-0022587; (E)-3-(3-(3-Hydroxy-2-piperidinyl)acetonyl)-4-(3H)-quinazolinone; (E)-3-(3-(3-Hydroxy-2-piperidinyl)-2-oxopropyl)-4(3H)-quinazolinone; 3-[3-[(2R,3S)-3-hydroxypiperidin-2-yl]-2-oxopropyl]quinazolin-4-one; trans-3-(beta-Keto-gamma-(3-hydroxy-2-piperidyl)propyl)-4-quinazolone; 4(3H)-Quinazolinone, 3-(3-(3-hydroxy-2-piperidinyl)-2-oxopropyl)-, (2S-trans)-; 9SF
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| Species Origin | Dichroa febrifuga ... | Click to Show/Hide | |||
| Dichroa febrifuga | |||||
| Disease | Blastomycosis [ICD-11: 1F22] | Investigative | [1] | ||
| Structure |
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| Formula |
C16H19N3O3
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| PubChem CID | |||||
| Canonical SMILES |
C1CC(C(NC1)CC(=O)CN2C=NC3=CC=CC=C3C2=O)O
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| InChI |
1S/C16H19N3O3/c20-11(8-14-15(21)6-3-7-17-14)9-19-10-18-13-5-2-1-4-12(13)16(19)22/h1-2,4-5,10,14-15,17,21H,3,6-9H2/t14-,15+/m1/s1
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| InChIKey |
FWVHWDSCPKXMDB-CABCVRRESA-N
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| CAS Number |
CAS 24159-07-7
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| Combinatorial Therapeutic Effect(s) Validated Clinically or Experimentally | ||||||
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| α. A List of Drug(s) Whose Efficacy can be Enhanced by This NP | ||||||
| Chloroquine | Malaria | Click to Show/Hide the Molecular Data of This Drug | ||||
| Achieving Therapeutic Synergy | Click to Show/Hide | |||||
| Representative Experiment Reporting the Effect of This Combination | [2] | |||||
| Detail(s) |
Combination Info
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| In-vivo Model | Mice were infected intraperitoneally with parasitized erythro-cytes. | |||||
| Experimental
Result(s) |
Malaria parasites in the mice given chloroquine plus alkaloids decreased on day 6 and then were not detected by a microscopic examination during observation period. | |||||
