Drug Combination Details
| General Information of the Combination (ID: C74677) | |||||
|---|---|---|---|---|---|
| Name | Honokiol NP Info | + | Gemcitabine Drug Info | ||
| Structure |
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+ |
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| Disease |
Pancreatic cancer
[ICD-11: 2C10]
|
Investigative | [1] | ||
| Combinatorial Therapeutic Effect(s) Validated Clinically or Experimentally | ||||||
|---|---|---|---|---|---|---|
| α. Enhancing Drug Efficacy by This Combination | ||||||
| Achieving Therapeutic Synergy | Click to Show/Hide | |||||
| Experiment 1 Reporting the Effect of This Combination | [1] | |||||
| Molecule(s)
Regulation |
Down-regulation | Phosphorylation | NFKBIA | Molecule Info |
Pathway MAP
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| Experimental
Result(s) |
Honokiol arrests cell cycle, induces apoptosis, and potentiates the cytotoxic effect of gemcitabine in human pancreatic cancer cells. | |||||
| References | ||||
|---|---|---|---|---|
| Reference 1 | Honokiol arrests cell cycle, induces apoptosis, and potentiates the cytotoxic effect of gemcitabine in human pancreatic cancer cells. PLoS One. 2011;6(6):e21573. | |||
