Drug Combination Details
| General Information of the Combination (ID: C75940) | |||||
|---|---|---|---|---|---|
| Name | Delta-9-tetrahydrocannabinol NP Info | + | Memantine Drug Info | ||
| Structure |
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+ |
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| Disease |
Parkinson's disease
[ICD-11: 8A00]
|
Investigative | [1] | ||
| Combinatorial Therapeutic Effect(s) Validated Clinically or Experimentally | ||||||
|---|---|---|---|---|---|---|
| α. Enhancing Drug Efficacy by This Combination | ||||||
| Achieving Therapeutic Synergy | Click to Show/Hide | |||||
| Experiment 1 Reporting the Effect of This Combination | [1] | |||||
| In-vivo Model | Haloperidol-induced tremulous jaw movements (TJMs) in rats were used as a model of parkinsonian-like tremor. | |||||
| Experimental
Result(s) |
Memantine and THC supra-additively inhibit haloperidol-induced TJMs, suggesting that co-administration of these drugs might be a new approach to the treatment of tremor. | |||||
