Drug Combination Details
| General Information of the Combination (ID: C76367) | |||||
|---|---|---|---|---|---|
| Name | Gossypol NP Info | + | Gemcitabine Drug Info | ||
| Structure |
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| Disease |
Nasopharyngeal cancer
[ICD-11: 2B6B]
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Investigative | [1] | ||
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Stomach cancer
[ICD-11: 2B72]
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Investigative | [1] | |||
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Breast cancer
[ICD-11: 2C60]
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Investigative | [1] | |||
| Combinatorial Therapeutic Effect(s) Validated Clinically or Experimentally | ||||||
|---|---|---|---|---|---|---|
| α. Reversing Drug Resistance by This Combination | ||||||
| Reversing Drug Resistance | Click to Show/Hide | |||||
| Experiment 1 Reporting the Effect of This Combination | [1] | |||||
| Molecule(s)
Regulation |
Down-regulation | Expression | BCL-2 | Molecule Info |
Pathway MAP
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| Down-regulation | Expression | BCL-xL | Molecule Info |
Pathway MAP
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| Up-regulation | Expression | PMAIP1 | Molecule Info |
Pathway MAP
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| In-vitro Model | CNE-1 | CVCL_6888 | Human nasopharyngeal carcinoma | Homo sapiens | ||
| CNE-2 | CVCL_6889 | Human nasopharyngeal carcinoma | Homo sapiens | |||
| HK-1 | CVCL_7047 | Lung large cell carcinoma | Homo sapiens | |||
| AGS | CVCL_0139 | Gastric adenocarcinoma | Homo sapiens | |||
| SNU-1 | CVCL_0099 | Gastric adenocarcinoma | Homo sapiens | |||
| YCC-16 | CVCL_9649 | Gastric adenocarcinoma | Homo sapiens | |||
| SK-BR-3 | CVCL_0033 | Breast adenocarcinoma | Homo sapiens | |||
| T-47D | CVCL_0553 | Invasive breast carcinoma | Homo sapiens | |||
| MCF-7 | CVCL_0031 | Invasive breast carcinoma | Homo sapiens | |||
| HONE | Nasopharyngeal carcinoma | Homo sapiens | ||||
| Experimental
Result(s) |
Combination therapy with gossypol reveals synergism against gemcitabine resistance in cancer cells with high BCL-2 expression. | |||||
| References | ||||
|---|---|---|---|---|
| Reference 1 | Combination therapy with gossypol reveals synergism against gemcitabine resistance in cancer cells with high BCL-2 expression. PLoS One. 2012;7(12):e50786. | |||
