Drug Combination Details
| General Information of the Combination (ID: C76673) | |||||
|---|---|---|---|---|---|
| Name | Flavopiridol NP Info | + | TNF-related apoptosis inducing ligand Drug Info | ||
| Structure |
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| Disease |
Breast cancer
[ICD-11: 2C60]
|
Investigative | [1] | ||
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B-cell lymphoma
[ICD-11: 2A86]
|
Investigative | [2] | |||
| Combinatorial Therapeutic Effect(s) Validated Clinically or Experimentally | ||||||
|---|---|---|---|---|---|---|
| α. Enhancing Drug Efficacy by This Combination | ||||||
| Augmenting Drug Sensitivity | Click to Show/Hide | |||||
| Experiment 1 Reporting the Effect of This Combination | [2] | |||||
| Molecule(s)
Regulation |
Up-regulation | Cleavage | BID | Molecule Info |
Pathway MAP
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| Up-regulation | Cleavage | CASP8 | Molecule Info |
Pathway MAP
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| Up-regulation | Cleavage | CASP9 | Molecule Info |
Pathway MAP
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| Down-regulation | Expression | CFLAR | Molecule Info |
Pathway MAP
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| Up-regulation | Cleavage | PARP1 | Molecule Info |
Pathway MAP
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| In-vitro Model | CLBL-1 | CVCL_L322 | Canine lymphoma | Canis lupus familiaris | ||
| Experimental
Result(s) |
Flavopiridol Strongly Sensitizes Canine Lymphoma Cells to TRAIL-induced Apoptosis by activation of both the extrinsic and the intrinsic branches of the apoptotic machinery. | |||||
| Experiment 2 Reporting the Effect of This Combination | [1] | |||||
| Molecule(s)
Regulation |
Up-regulation | Cleavage | CASP8 | Molecule Info |
Pathway MAP
|
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| Down-regulation | Expression | CFLAR | Molecule Info |
Pathway MAP
|
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| Biological
Regulation |
Up-regulation | Death-inducing signaling complex (DISC) formation | ||||
| Up-regulation | Cytochrome c release | |||||
| In-vitro Model | MCF-7 | CVCL_0031 | Invasive breast carcinoma | Homo sapiens | ||
| MDA-MB-231 | CVCL_0062 | Breast adenocarcinoma | Homo sapiens | |||
| Evsa-T | CVCL_1207 | Breast carcinoma | Homo sapiens | |||
| Jurkat | CVCL_0065 | T acute lymphoblastic leukemia | Homo sapiens | |||
| MDA-MB-468 | CVCL_0419 | Breast adenocarcinoma | Homo sapiens | |||
| SK-BR-3 | CVCL_0033 | Breast adenocarcinoma | Homo sapiens | |||
| BT-474 | CVCL_0179 | Invasive breast carcinoma | Homo sapiens | |||
| Experimental
Result(s) |
Flavopiridol sensitizes breast cancer cells to TRAIL-induced apoptosis by facilitating early events in the apoptotic pathway. | |||||
