Drug Combination Details
| General Information of the Combination (ID: C76700) | |||||
|---|---|---|---|---|---|
| Name | Cryptolepine NP Info | + | Mesalazine Drug Info | ||
| Structure |
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+ |
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| Disease |
Ulcerative colitis
[ICD-11: DD71]
|
Investigative | [1] | ||
| Combinatorial Therapeutic Effect(s) Validated Clinically or Experimentally | ||||||
|---|---|---|---|---|---|---|
| α. Enhancing Drug Efficacy by This Combination | ||||||
| Achieving Therapeutic Synergy | Click to Show/Hide | |||||
| Experiment 1 Reporting the Effect of This Combination | [1] | |||||
| In-vivo Model | Healthy adult male Wistar rats (220-250 g) were used throughout the study. | |||||
| Experimental
Result(s) |
Crocin and mesalazine produced protective effects on colon tissue via antioxidant and anti-inflammatory actions. In addition, a synergistic effect was observed between crocin and mesalazine in attenuating ulcerative colitis. | |||||
| References | ||||
|---|---|---|---|---|
| Reference 1 | The effects of crocin, mesalazine and their combination in the acetic acid-induced colitis in rats. Vet Res Forum. Summer 2019;10(3):227-234. | |||
