Natural Product (NP) Details

General Information of the NP (ID: NP8440)
Name
Cryptolepine
Synonyms
Cryptolepine; 480-26-2; CCRIS 9019; 5H-Quindoline, 5-methyl-; 5-METHYL-5H-INDOLO[3,2-B]QUINOLINE; 5-methylindolo[3,2-b]quinoline; Cryptolepine hydrate; OF1UIT4RDH; UNII-OF1UIT4RDH; CHEBI:3930; NSC647765; 5-Methylquindoline; C09142; SCHEMBL542771; CHEMBL119096; 5-Methyl-5H-quindoline hydrate; DTXSID6037645; ZINC898100; BDBM50412201; MFCD17215953; Q5190964
    Click to Show/Hide
Species Origin Cryptolepis sinensis ...     Click to Show/Hide
Cryptolepis sinensis
Kingdom: Viridiplantae
Phylum: Streptophyta
Class: Magnoliopsida
Order: Gentianales
Family: Apocynaceae
Genus: Cryptolepis
Species: Cryptolepis sinensis
Disease Malaria [ICD-11: 1F40] Investigative [1]
Structure
Click to Download Mol
2D MOL

3D MOL

    Click to Show/Hide the Molecular Information and External Link(s) of This Natural Product
Formula
C16H12N2
PubChem CID
82143
Canonical SMILES
CN1C2=CC=CC=C2C=C3C1=C4C=CC=CC4=N3
InChI
1S/C16H12N2/c1-18-15-9-5-2-6-11(15)10-14-16(18)12-7-3-4-8-13(12)17-14/h2-10H,1H3
InChIKey
KURWKDDWCJELSV-UHFFFAOYSA-N
CAS Number
CAS 480-26-2
ChEBI ID
CHEBI:3930
Herb ID
HBIN021782
Combinatorial Therapeutic Effect(s) Validated Clinically or Experimentally
    α. A List of Drug(s) Whose Efficacy can be Enhanced by This NP
          Mesalazine      Ulcerative colitis     Click to Show/Hide the Molecular Data of This Drug
                 Achieving Therapeutic Synergy     Click to Show/Hide
                    Representative Experiment Reporting the Effect of This Combination [2]
                    Detail(s)  Combination Info  click to show the detail info of this combination
                    In-vivo Model Healthy adult male Wistar rats (220-250 g) were used throughout the study.
                    Experimental
                    Result(s)		 Crocin and mesalazine produced protective effects on colon tissue via antioxidant and anti-inflammatory actions. In addition, a synergistic effect was observed between crocin and mesalazine in attenuating ulcerative colitis.
References
Reference 1 In vitro anti-malarial interaction and gametocytocidal activity of cryptolepine. Malar J. 2017 Dec 28;16(1):496.
Reference 2 The effects of crocin, mesalazine and their combination in the acetic acid-induced colitis in rats. Vet Res Forum. Summer 2019;10(3):227-234.
 Download Picture         KEGG Link