Drug Combination Details

General Information of the Combination (ID: C79731)
Name Theanine   NP Info  + Doxorubicin   Drug Info 
Structure +
Disease
Ovarian cancer [ICD-11: 2C73]
Investigative [1]
Combinatorial Therapeutic Effect(s) Validated Clinically or Experimentally
    α. Enhancing Drug Efficacy by This Combination
                 Achieving Therapeutic Synergy     Click to Show/Hide
                    Experiment 1 Reporting the Effect of This Combination [1]
                    In-vitro Model M5076 CVCL_3997 Mouse ovarian histiocytic sarcoma Mus musculus
                    In-vivo Model M5076 ovarian sarcoma (1 * 106 cells/mouse) were s.c. transplanted onto the backs of BDF1 mice.
                    Experimental
                    Result(s)		 Theanine increased not only the antitumor activity on primary tumor but also the metastasis-suppressive efficacy of doxorubicin.
References
Reference 1 Combination of theanine with doxorubicin inhibits hepatic metastasis of M5076 ovarian sarcoma. Clin Cancer Res. 1999 Feb;5(2):413-6.
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