Drug Combination Details

General Information of the Combination (ID: C80540)
Name L-arginine + Phentolamine + Sildenafil
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Name L-arginine   NP Info     Drug Info 
Structure
Name    Drug Info 
Structure
Disease
Erectile dysfunction [ICD-11: HA01]
Investigative [1]
Combinatorial Therapeutic Effect(s) Validated Clinically or Experimentally
    α. Enhancing Drug Efficacy by This Combination
                 Achieving Therapeutic Synergy     Click to Show/Hide
                    Experiment 1 Reporting the Effect of This Combination [1]
                    Biological
                    Regulation		 Increase Maximum relaxation
                    In-vivo Model Male New Zealand white rabbits (3 to 3.5kg) were used in this study.
                    Experimental
                    Result(s)		 The study demonstrated a synergistic interaction between the alpha-adrenergic blockade and the potentiation of the nitric oxide/cyclic guanosine monophosphate pathway to increase neurogenic relaxation of trabecular smooth muscle relaxation.
References
Reference 1 Combination of phentolamine and L-arginine or sildenafil synergistically improves neurogenic relaxation of rabbit corpus cavernosum smooth muscle. Urology. 2001 Mar;57(3):585-9.
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