Natural Product (NP) Details

General Information of the NP (ID: NP0067)
Name
L-arginine
Synonyms
L-arginine; arginine; 74-79-3; L-(+)-Arginine; L(+)-Arginine; L-Arg; H-Arg-OH; (S)-2-Amino-5-guanidinopentanoic acid; (L)-Arginine; Arginina; ARGININE, L-; Arginine (VAN); L-Arginin; Argininum [INN-Latin]; Arginina [INN-Spanish]; L-Ornithine, N5-(aminoiminomethyl)-; Argamine; Argivene; Detoxargin; Levargin; L-alpha-Amino-delta-guanidinovaleric acid; Minophagen A; 1-Amino-4-guanidovaleric acid; CCRIS 3609; NSC 206269; arg; HSDB 1429; AI3-24165; UNII-94ZLA3W45F; MFCD00002635; (S)-2-Amino-5-guanidinovaleric acid; BRN 1725413; CHEBI:16467; (S)-2-Amino-5-((aminoiminomethyl)amino)pentanoic acid; L-Norvaline, 5-((aminoiminomethyl)amino)-; (S)-(+)-arginine; L-Arginine, monohydrochloride; 2-amino-5-guanidinovaleric acid; CHEMBL1485; (2S)-2-amino-5-guanidinopentanoic acid; (S)-2-Amino-5-[(aminoiminomethyl)amino]pentanoic acid; 94ZLA3W45F; Pentanoic acid, 2-amino-5-((aminoiminomethyl)amino)-, (S)-; (2S)-2-amino-5-(carbamimidamido)pentanoic acid; L-2-Amino-5-guanidinopentanoic acid; Arginine (L-Arginine); R-Gene; L-Norvaline, 5-[(aminoiminomethyl)amino]-; (2S)-2-amino-5-carbamimidamidopentanoic acid; DSSTox_CID_21056; DSSTox_RID_79618; Poly(L-arginine); DSSTox_GSID_41056; L(+)-Arginine, 98+%; C6H14N4O2; Argininum; Pentanoic acid, 2-amino-5-[(aminoiminomethyl)amino]-, (S)-; L-Arginine, homopolymer; Arginine [USAN:INN]; (2S)-2-amino-5-(diaminomethylideneamino)pentanoic acid; CAS-74-79-3; Arginine [USP:INN]; EINECS 200-811-1; 2-AMINO-5-GUANIDINO-PENTANOIC ACID; (2S)-2-azanyl-5-[bis(azanyl)methylideneamino]pentanoic acid; NSC203450; 3h-l-arginine; L-Arginine, labeled with tritium; 1laf; NSC-206269; L-a-Amino-d-guanidinovaleric acid; NCGC00015064-02; (S)-Arginine; L(+) arginine; L-Aryginine,(S); cyclohexyl-l-alanine; H-Arg; L-(+) arginine; L(+)-Arginine;; PubChem7933; L-Arginine (9CI); Arginine (USP/INN); Tocris-0663; (2S)-2-amino-5-guanidino-pentanoic acid; L-Arginine (JP17); GND; Lopac-A-5006; Arginine, L- (8CI); bmse000029; bmse000899; bmse000919; Epitope ID:140084; L-Arginine (H-Arg-OH); EC 200-811-1; SCHEMBL1791; 2-amino-5-guanidinovalerate; Lopac0_000077; Arginine hydrochloride(USAN); GTPL721; 4-04-00-02648 (Beilstein Handbook Reference); L-a-Amino-d-guanidinovalerate; L-Amino-4-guanidovaleric acid; US9138393, L-Arginine; US9144538, L-Arginine; 1-Amino-4-guanidovalerlic acid; DTXSID6041056; BDBM21959; L-Arginine, 99%, FCC, FG; BDBM181132; HMS3260O15; N5-(aminoiminomethyl)-L-Ornithine; HY-N0455; ZINC1532525; L-Arginine, Vetec(TM), 98.5%; Tox21_113046; Tox21_500077; AC-083; ANW-36527; L-alpha-Amino-delta-guanidinovalerate; L-Arginine, reagent grade, >=98%; s5634; AKOS006239069; AKOS015854096; Tox21_113046_1; AM81500; CCG-204172; DB00125; LP00077; MCULE-5108123240; SDCCGSBI-0050065.P002; L-Arginine, 99%, natural, FCC, FG; (s)-2-amino-5-guanidino-pentanoic acid; 5-[(aminoiminomethyl)amino]-L-Norvaline; NCGC00015064-01; NCGC00024715-01; NCGC00024715-02; NCGC00024715-03; NCGC00024715-04; NCGC00024715-05; NCGC00024715-10; NCGC00260762-01; 25212-18-4; 4455-52-1; AK-81231; AS-14190; K277; L-Arginine, BioUltra, >=99.5% (NT); SBI-0207062.P001; AB0014136; A0526; A7079; EU-0100077; L-Arginine, SAJ special grade, >=98.0%; A 5006; C00062; D02982; L-Arginine, Vetec(TM) reagent grade, >=98%; M02981; Y-8965; 14932-EP2316830A2; AB00374192_03; Norvaline, 5-[(aminoiminomethyl)amino]-, (L)-; 002A635; A837397; Q173670; SR-01000075479; SR-01000597671; (S)-2-amino-5-[(aminoiminomethyl)amino]-Pentanoate; (S)-2-Amino-5-[(aminoiminomethyl)amino]pentanoate; SR-01000075479-1; SR-01000597671-1; W-104410; (S)-2-amino-5-[(aminoiminomethyl)amino]-Pentanoic acid; Arginine, European Pharmacopoeia (EP) Reference Standard; (2S)-2-amino-5-[(diaminomethylidene)amino]pentanoic acid; 7F15B0C7-356D-45D7-AC33-03AEE4394A0E; S-(+)-2-Amino-5-[(aminoiminomethyl)amino]pentanoic acid; UNII-0O72R8RF8A component ODKSFYDXXFIFQN-BYPYZUCNSA-N; UNII-FL26NTK3EP component ODKSFYDXXFIFQN-BYPYZUCNSA-N; L-Arginine, United States Pharmacopeia (USP) Reference Standard; L-Arginine, Pharmaceutical Secondary Standard; Certified Reference Material; L-; L-Arginine, from non-animal source, meets EP, USP testing specifications, suitable for cell culture, 98.5-101.0%; L-Arginine, PharmaGrade, Ajinomoto, EP, USP, manufactured under appropriate GMP controls for Pharma or Biopharmaceutical production, suitable for cell culture
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Species Origin Escherichia coli ...     Click to Show/Hide
Escherichia coli
SuperKingdom: Bacteria
Phylum: Proteobacteria
Class: Gammaproteobacteria
Order: Enterobacterales
Family: Enterobacteriaceae
Genus: Escherichia
Species: Escherichia coli
Disease Pituitary gland disorder [ICD-11: 5A61] Approved [1]
Structure
Click to Download Mol
2D MOL

3D MOL

ADMET Property
Absporption
Caco-2 Permeability
 -6.058
 
MDCK Permeability
 -4.357
 
PAMPA
 +++
 
HIA
 - - -
 
Distribution
VDss
 -0.361
 
PPB
 11.4%
 
BBB
 - - -
 
Metabolism
CYP1A2 inhibitor
 - - -
CYP1A2 substrate
 - - -
CYP2C19 inhibitor
 - - -
CYP2C19 substrate
 - - -
CYP2C9 inhibitor
 - - -
CYP2C9 substrate
 - - -
CYP2D6 inhibitor
 - - -
CYP2D6 substrate
 +++
CYP3A4 inhibitor
 - - -
CYP3A4 substrate
 -
CYP2B6 inhibitor
 - - -
CYP2B6 substrate
 - - -
CYP2C8 inhibitor
 - - -
HLM Stability
 - - -
 
Excretion
CLplasma
 2.492
 
T1/2
 1.968
Toxicity
DILI
 - - -
 
Rat Oral Acute Toxicity
 +
 
FDAMDD
 - -
 
Respiratory
 +
 
Human Hepatotoxicity
 - -
 
Ototoxicity
 -
 
Drug-induced Nephrotoxicity
 - -
 
Drug-induced Neurotoxicity
 - -
 
Hematotoxicity
 - -
 
Genotoxicity
 ++
 
Tips: 1. For the classification endpoints, the prediction probability values are transformed into six symbols: 0-0.1 (- - -), 0.1-0.3 (- -), 0.3-0.5 (-), 0.5-0.7 (+), 0.7-0.9 (++), and 0.9-1.0 (+++). 2. Additionally, the corresponding relationships of the three labels are as follows: excellent; medium; poor.
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    Click to Show/Hide the Molecular Information and External Link(s) of This Natural Product
Formula
C6H14N4O2
PubChem CID
6322
Canonical SMILES
C(CC(C(=O)O)N)CN=C(N)N
InChI
1S/C6H14N4O2/c7-4(5(11)12)2-1-3-10-6(8)9/h4H,1-3,7H2,(H,11,12)(H4,8,9,10)/t4-/m0/s1
InChIKey
ODKSFYDXXFIFQN-BYPYZUCNSA-N
CAS Number
CAS 74-79-3
ChEBI ID
CHEBI:16467
Herb ID
HBIN016720
SymMap ID
SMIT18757
TTD Drug ID
D0F5DO
Combinatorial Therapeutic Effect(s) Validated Clinically or Experimentally
    α. A List of Drug(s) Whose Efficacy can be Enhanced by This NP
          Phentolamine + Sildenafil     Click to Show/Hide the Molecular Data of This Drug
                 Achieving Therapeutic Synergy     Click to Show/Hide
                    Representative Experiment Reporting the Effect of This Combination [2]
                    Detail(s)  Combination Info  click to show the detail info of this combination
                    Biological
                    Regulation		 Increase Maximum relaxation
                    In-vivo Model Male New Zealand white rabbits (3 to 3.5kg) were used in this study.
                    Experimental
                    Result(s)		 The study demonstrated a synergistic interaction between the alpha-adrenergic blockade and the potentiation of the nitric oxide/cyclic guanosine monophosphate pathway to increase neurogenic relaxation of trabecular smooth muscle relaxation.
References
Reference 1 Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015
Reference 2 Combination of phentolamine and L-arginine or sildenafil synergistically improves neurogenic relaxation of rabbit corpus cavernosum smooth muscle. Urology. 2001 Mar;57(3):585-9.
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