Drug Combination Details
| General Information of the Combination (ID: C80914) | |||||
|---|---|---|---|---|---|
| Name | Allyl isothiocyanate NP Info | + | Celecoxib Drug Info | ||
| Structure |
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+ |
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| Disease |
Bladder cancer
[ICD-11: 2C94]
|
Investigative | [1] | ||
| Combinatorial Therapeutic Effect(s) Validated Clinically or Experimentally | ||||||
|---|---|---|---|---|---|---|
| α. Enhancing Drug Efficacy by This Combination | ||||||
| Achieving Therapeutic Synergy | Click to Show/Hide | |||||
| Experiment 1 Reporting the Effect of This Combination | [1] | |||||
| Molecule(s)
Regulation |
Up-regulation | Expression | CASP3 | Molecule Info |
Pathway MAP
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| Down-regulation | Expression | COX-2 | Molecule Info |
Pathway MAP
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| Down-regulation | Expression | PTGER2 | Molecule Info |
Pathway MAP
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| Down-regulation | Expression | VEGFA | Molecule Info |
Pathway MAP
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| In-vitro Model | AY-27 | CVCL_S825 | Rat urinary system neoplasms | Rattus norvegicus | ||
| In-vivo Model | Female F344 rats (Harlan) at 9-10 weeks of age were anesthetized with ketamine and xylazine. | |||||
| Experimental
Result(s) |
The combination regime was more effective than each single agent in inhibiting microvessel formation and stimulating microvessel maturation in the tumor tissues. | |||||
| References | ||||
|---|---|---|---|---|
| Reference 1 | Enhanced inhibition of urinary bladder cancer growth and muscle invasion by allyl isothiocyanate and celecoxib in combination. Carcinogenesis. 2013 Nov;34(11):2593-9. | |||
