Drug Combination Details
| General Information of the Combination (ID: C80977) | |||||
|---|---|---|---|---|---|
| Name | Carnosic acid NP Info | + | 1,25-dihydroxyvitamin D3 Drug Info | ||
| Structure |
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+ |
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| Disease |
Acute lymphoblastic leukemia
[ICD-11: 2B33]
|
Investigative | [1] | ||
| Combinatorial Therapeutic Effect(s) Validated Clinically or Experimentally | ||||||
|---|---|---|---|---|---|---|
| α. Enhancing Drug Efficacy by This Combination | ||||||
| Augmenting Drug Sensitivity | Click to Show/Hide | |||||
| Experiment 1 Reporting the Effect of This Combination | [1] | |||||
| Molecule(s)
Regulation |
Up-regulation | Phosphorylation | c-RAF | Molecule Info |
Pathway MAP
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| Up-regulation | Phosphorylation | ERK1 | Molecule Info |
Pathway MAP
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| Up-regulation | Phosphorylation | ERK2 | Molecule Info |
Pathway MAP
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| Up-regulation | Phosphorylation | MEK1 | Molecule Info |
Pathway MAP
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| Up-regulation | Phosphorylation | RSK1 | Molecule Info |
Pathway MAP
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| In-vitro Model | HL-60 | CVCL_0002 | Adult acute myeloid leukemia | Homo sapiens | ||
| Experimental
Result(s) |
Carnosic acid potentiates the antioxidant and prodifferentiation effects of 1alpha,25-dihydroxyvitamin D3 in leukemia cells but does not promote elevation of basal levels of intracellular calcium. | |||||
