Drug Combination Details

General Information of the Combination (ID: C81435)
Name Honokiol   NP Info  + Temozolomide   Drug Info 
Structure +
Disease
Brain cancer [ICD-11: 2A00]
Investigative [1]
Combinatorial Therapeutic Effect(s) Validated Clinically or Experimentally
    α. Enhancing Drug Efficacy by This Combination
                 Achieving Therapeutic Synergy     Click to Show/Hide
                    Experiment 1 Reporting the Effect of This Combination [1]
                    Molecule(s)
                    Regulation		 Up-regulation Expression CASP3  Molecule Info 
Pathway MAP
                    In-vitro Model U-87MG ATCC CVCL_0022 Glioblastoma Homo sapiens
GL261 CVCL_Y003 Mouse glioblastoma Mus musculus
                    Experimental
                    Result(s)		 Honokiol enhanced temozolomide-induced autophagy and apoptosis in drug-sensitive and -tolerant glioma cells.
                    Experiment 2 Reporting the Effect of This Combination [2]
                    Molecule(s)
                    Regulation		 Down-regulation Expression NOTCH3  Molecule Info 
Pathway MAP
                    In-vitro Model GBM8401 CVCL_B051 Glioblastoma Homo sapiens
                    Experimental
                    Result(s)		 Honokiol eliminates cancer stem-like cells and potentiates temozolomide sensitivity glioblastoma multiforme cells.
References
Reference 1 Improved effects of honokiol on temozolomide-induced autophagy and apoptosis of drug-sensitive and -tolerant glioma cells. BMC Cancer. 2018 Apr 3;18(1):379.
Reference 2 Elimination of cancer stem-like cells and potentiation of temozolomide sensitivity by Honokiol in glioblastoma multiforme cells. PLoS One. 2015 Mar 12;10(3):e0114830.
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