Drug Combination Details
| General Information of the Combination (ID: C82034) | |||||
|---|---|---|---|---|---|
| Name | Progesterone NP Info | + | Temozolomide Drug Info | ||
| Structure |
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+ |
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| Disease |
Brain cancer
[ICD-11: 2A00]
|
Investigative | [1] | ||
| Combinatorial Therapeutic Effect(s) Validated Clinically or Experimentally | ||||||
|---|---|---|---|---|---|---|
| α. Enhancing Drug Efficacy by This Combination | ||||||
| Achieving Therapeutic Synergy | Click to Show/Hide | |||||
| Experiment 1 Reporting the Effect of This Combination | [1] | |||||
| Molecule(s)
Regulation |
Down-regulation | Expression | EGFR | Molecule Info |
Pathway MAP
|
|
| In-vitro Model | U-87MG ATCC | CVCL_0022 | Glioblastoma | Homo sapiens | ||
| U-118MG | CVCL_0633 | Glioma | Homo sapiens | |||
| Experimental
Result(s) |
PROG enhances the cytotoxic effects of TMZ in GBM cells and reduces its toxic side effects in healthy primary cells. | |||||
| References | ||||
|---|---|---|---|---|
| Reference 1 | Targeting Glioma Initiating Cells with A combined therapy of cannabinoids and temozolomide. Biochem Pharmacol. 2018 Nov;157:266-274. | |||
