Drug Combination Details
| General Information of the Combination (ID: C84114) | |||||
|---|---|---|---|---|---|
| Name | Selenium NP Info | + | Cis-diamminedichloroplatinum Drug Info | ||
| Structure |
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+ |
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| Disease |
Murine fibrosarcoma
[ICD-11: 2B5J]
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Investigative | [1] | ||
| Combinatorial Therapeutic Effect(s) Validated Clinically or Experimentally | ||||||
|---|---|---|---|---|---|---|
| α. Decreasing Adverse Drug Reaction by This Combination | ||||||
| Decreasing Adverse Drug Reaction | Click to Show/Hide | |||||
| Experiment 1 Reporting the Effect of This Combination | [1] | |||||
| In-vitro Model | MC B6-1 cells dissociated from solid tumor | Fibrosarcoma | Rattus norvegicus | |||
| In-vivo Model | The MC B6-1 fibrosarcoma was originally induced by s.c.injection of 2 mg of methylcholanthrene in a female C57BL/6 mouse and serially transplanted in syngeneic mice. | |||||
| Experimental
Result(s) |
The addition of selenium decreases the nephrotoxicity of cis-DDP. | |||||
| References | ||||
|---|---|---|---|---|
| Reference 1 | Effect of selenium in combination with cis-diamminedichloroplatinum(II) in the treatment of murine fibrosarcoma. Cancer Res. 1984 Jul;44(7):2864-8. | |||
