Drug Details

General Information of the Drug (ID: DR8104)
Name
Cis-diamminedichloroplatinum
Synonyms
cis-Platin; cis-DDP; Cisplatine; Cisplatino; Cisplatinum; Lederplatin; Briplatin; Cismaplat; Neoplatin; Platamine; Platinex; Randa; trans-platin; cis-Dichlorodiammineplatinum(II); Peyrone's salt; cis-Diamminedichloroplatinum; Peyrone's chloride; trans-Platinum(II) ammonium chloride; cis-[PtCl2(NH3)2]; trans-Dichlorodiammine platinum; trans-Platinumdiammine dichloride; CHEBI:27899; CHEBI:35852; TRANS-DIAMMINEDICHLOROPLATINUM; trans-Platinum(II) diamminedichloride; trans-DDP, 8; Cisplatin, 1; Epitope ID:194799; Epitope ID:194800; BDBM92386; cis-diamminedichloridoplatinum(II); (SP-4-1)-diamminedichloroplatinum; (SP-4-2)-diamminedichloroplatinum; trans-diamminedichloridoplatinum(II); (SP-4-1)-diamminedichloridoplatinum; (SP-4-2)-diamminedichloridoplatinum; AKOS025117566; DB00515; EU-0100918
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Molecular Type
Small molecule
Disease Ovarian cancer [ICD-11: 2C73] Approved [1]
Structure
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2D MOL

3D MOL

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Formula
Cl2H6N2Pt+2
PubChem CID
441203
Canonical SMILES
N.N.Cl[Pt+2]Cl
InChI
1S/2ClH.2H3N.Pt/h2*1H;2*1H3;/q;;;;+4/p-2
InChIKey
BSJGASKRWFKGMV-UHFFFAOYSA-L
CAS Number
CAS 15663-27-1
ChEBI ID
CHEBI:27899
DrugBank ID
DB00515
Combinatorial Therapeutic Effect(s) Validated Clinically or Experimentally
    α. A List of Natural Product(s) Able to Enhance the Efficacy of This Drug
          Antineoplaston A10      Homo sapiens     Click to Show/Hide the Molecular Data of This NP
                 Achieving Therapeutic Synergy     Click to Show/Hide
                    Representative Experiment Reporting the Effect of This Combination [2]
                    Detail(s)  Combination Info  click to show the detail info of this combination
                    In-vitro Model KIM-1 CVCL_7969 Adult hepatocellular carcinoma Homo sapiens
                    In-vivo Model The KIM-1 cell suspension was implanted subcutaneously in BALB/c athymic mice.
                    Experimental
                    Result(s)		 The inhibitory effect of the combination of antineoplaston A-10 injection with a small dose of cis-diamminedichloroplatinum on cell and tumor growth of human hepatocellular carcinoma.
          Quercetin      Averrhoa carambola     Click to Show/Hide the Molecular Data of This NP
                 Achieving Therapeutic Synergy     Click to Show/Hide
                    Representative Experiment Reporting the Effect of This Combination [3]
                    Detail(s)  Combination Info  click to show the detail info of this combination
                    In-vitro Model LXFL 529L CVCL_D085 Lung non-small cell carcinoma Homo sapiens
                    Experimental
                    Result(s)		 Quercetin enhances the antiproliferative activity of cis-diamminedichloroplatinum (II) in lung cancer cells.
    β. A List of Natural Product(s) Able to Decrease the Adverse Effect of This Drug
          Selenium      Soil     Click to Show/Hide the Molecular Data of This NP
                 Decreasing Adverse Drug Reaction     Click to Show/Hide
                    Representative Experiment Reporting the Effect of This Combination [4]
                    Detail(s)  Combination Info  click to show the detail info of this combination
                    In-vitro Model MC B6-1 cells dissociated from solid tumor Fibrosarcoma Rattus norvegicus
                    In-vivo Model The MC B6-1 fibrosarcoma was originally induced by s.c.injection of 2 mg of methylcholanthrene in a female C57BL/6 mouse and serially transplanted in syngeneic mice.
                    Experimental
                    Result(s)		 The addition of selenium decreases the nephrotoxicity of cis-DDP.
References
Reference 1 Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health Human Services. 2019
Reference 2 The inhibitory effect of the combination of antineoplaston A-10 injection with a small dose of cis-diamminedichloroplatinum on cell and tumor growth of human hepatocellular carcinoma. Jpn J Cancer Res. 1992 May;83(5):527-31.
Reference 3 Enhancement of the antiproliferative activity of cis-diamminedichloroplatinum(II) by quercetin. Int J Cancer. 1990 Mar 15;45(3):536-9.
Reference 4 Effect of selenium in combination with cis-diamminedichloroplatinum(II) in the treatment of murine fibrosarcoma. Cancer Res. 1984 Jul;44(7):2864-8.
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