Drug Combination Details
| General Information of the Combination (ID: C84395) | |||||
|---|---|---|---|---|---|
| Name | Carnosic acid NP Info | + | Cisplatin Drug Info | ||
| Structure |
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| Disease |
Lung cancer
[ICD-11: 2C25]
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Investigative | [1] | ||
| Combinatorial Therapeutic Effect(s) Validated Clinically or Experimentally | ||||||
|---|---|---|---|---|---|---|
| α. Enhancing Drug Efficacy by This Combination | ||||||
| Augmenting Drug Sensitivity | Click to Show/Hide | |||||
| Experiment 1 Reporting the Effect of This Combination | [1] | |||||
| Molecule(s)
Regulation |
Down-regulation | Expression | ARG1 | Molecule Info |
Pathway MAP
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| Up-regulation | Expression | CD178 | Molecule Info |
Pathway MAP
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| Up-regulation | Expression | GZMB | Molecule Info |
Pathway MAP
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| Up-regulation | Expression | IFNG | Molecule Info |
Pathway MAP
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| Down-regulation | Expression | MMP-9 | Molecule Info |
Pathway MAP
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| Up-regulation | Expression | PRF1 | Molecule Info |
Pathway MAP
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| In-vivo Model | Mouse LLC (Lewis lung cancer) cells (5*106 cells in 0.1 mL) were injected into the right flank of C57BL/6 mice. | |||||
| Experimental
Result(s) |
Carnosic acid enhances the anti-lung cancer effect of cisplatin by inhibiting myeloid-derived suppressor cells. | |||||
| References | ||||
|---|---|---|---|---|
| Reference 1 | Carnosic acid enhances the anti-lung cancer effect of cisplatin by inhibiting myeloid-derived suppressor cells. Chin J Nat Med. 2018 Dec;16(12):907-915. | |||
