Drug Combination Details
| General Information of the Combination (ID: C85377) | |||||
|---|---|---|---|---|---|
| Name | Elemene NP Info | + | 5-fluorouracil Drug Info | ||
| Structure |
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+ |
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| Disease |
Breast cancer
[ICD-11: 2C60]
|
Investigative | [1] | ||
| Combinatorial Therapeutic Effect(s) Validated Clinically or Experimentally | ||||||
|---|---|---|---|---|---|---|
| α. Enhancing Drug Efficacy by This Combination | ||||||
| Achieving Therapeutic Synergy | Click to Show/Hide | |||||
| Experiment 1 Reporting the Effect of This Combination | [1] | |||||
| Molecule(s)
Regulation |
Down-regulation | Phosphorylation | AKT1 | Molecule Info |
Pathway MAP
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| Down-regulation | Phosphorylation | c-RAF | Molecule Info |
Pathway MAP
|
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| Down-regulation | Phosphorylation | CYB5R2 | Molecule Info |
Pathway MAP
|
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| Down-regulation | Phosphorylation | ERK1 | Molecule Info |
Pathway MAP
|
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| Down-regulation | Expression | PIK3R1 | Molecule Info |
Pathway MAP
|
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| In-vitro Model | BT-549 | CVCL_1092 | Invasive breast carcinoma | Homo sapiens | ||
| MDA-MB-231 | CVCL_0062 | Breast adenocarcinoma | Homo sapiens | |||
| In-vivo Model | MDA-MB-231 cells (5*106 cells in 100 uL of PBS) were subcutaneously injected to the left flank of femal nude mice. | |||||
| Experimental
Result(s) |
Beta-Elemene enhances the chemotherapeutic effect of 5-Fluorouracil in triple-negative breast cancer via PI3K/AKT, RAF-MEK-ErK, and NF-KappaB signaling pathways. | |||||
| Augmenting Drug Sensitivity | Click to Show/Hide | |||||
| Experiment 1 Reporting the Effect of This Combination | [1] | |||||
| Molecule(s)
Regulation |
Down-regulation | Phosphorylation | AKT1 | Molecule Info |
Pathway MAP
|
|
| Down-regulation | Phosphorylation | c-RAF | Molecule Info |
Pathway MAP
|
||
| Down-regulation | Phosphorylation | CYB5R2 | Molecule Info |
Pathway MAP
|
||
| Down-regulation | Phosphorylation | ERK1 | Molecule Info |
Pathway MAP
|
||
| Down-regulation | Expression | PIK3R1 | Molecule Info |
Pathway MAP
|
||
| In-vitro Model | BT-549 | CVCL_1092 | Invasive breast carcinoma | Homo sapiens | ||
| MDA-MB-231 | CVCL_0062 | Breast adenocarcinoma | Homo sapiens | |||
| In-vivo Model | MDA-MB-231 cells (5*106 cells in 100L of PBS) were subcutaneously injected to the left flank of each female nude mice. | |||||
| Experimental
Result(s) |
beta-Elemene Enhances the chemotherapeutic effect of 5-Fluorouracil in triple-negative breast cancer via PI3K/AKT, RAF-MEK-ErK, and NF-kappaB signaling pathways. | |||||
