Drug Combination Details

General Information of the Combination (ID: C85406)
Name Esculetin   NP Info  + TNF-related apoptosis inducing ligand    Drug Info 
Structure +
Disease
Lip/oral cavity/pharynx neoplasm [ICD-11: 2B6E]
Investigative [1]
Combinatorial Therapeutic Effect(s) Validated Clinically or Experimentally
    α. Enhancing Drug Efficacy by This Combination
                 Augmenting Drug Sensitivity     Click to Show/Hide
                    Experiment 1 Reporting the Effect of This Combination [1]
                    Molecule(s)
                    Regulation		 Up-regulation Expression TRAIL-R2  Molecule Info 
Pathway MAP
                    In-vitro Model SAS CVCL_1675 Tongue squamous cell carcinoma Homo sapiens
                    Experimental
                    Result(s)		 Esculetin enhances TRAIL-induced apoptosis primarily through upregulation of DR5.
References
Reference 1 Esculetin enhances TRAIL-induced apoptosis through DR5 upregulation in human oral cancer SAS cells. Oral Oncol. 2009 Dec;45(12):1067-72.
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