Drug Combination Details
| General Information of the Combination (ID: C86383) | |||||
|---|---|---|---|---|---|
| Name | Triptolide NP Info | + | BIIB021 Drug Info | ||
| Structure |
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| Disease |
Thyroid cancer
[ICD-11: 2D10]
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Investigative | [1] | ||
| Combinatorial Therapeutic Effect(s) Validated Clinically or Experimentally | ||||||
|---|---|---|---|---|---|---|
| α. Enhancing Drug Efficacy by This Combination | ||||||
| Achieving Therapeutic Synergy | Click to Show/Hide | |||||
| Experiment 1 Reporting the Effect of This Combination | [1] | |||||
| Molecule(s)
Regulation |
Down-regulation | Expression | AKT1 | Molecule Info |
Pathway MAP
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| Down-regulation | Expression | BIRC5 | Molecule Info |
Pathway MAP
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| Up-regulation | Expression | CASP3 | Molecule Info |
Pathway MAP
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| Down-regulation | Phosphorylation | EIF4EBP1 | Molecule Info |
Pathway MAP
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| Down-regulation | Phosphorylation | mTOR | Molecule Info |
Pathway MAP
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| Down-regulation | Phosphorylation | p105 | Molecule Info |
Pathway MAP
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| Down-regulation | Phosphorylation | S6K1 | Molecule Info |
Pathway MAP
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| Up-regulation | Expression | TP53 | Molecule Info |
Pathway MAP
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| Down-regulation | Expression | XIAP | Molecule Info |
Pathway MAP
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| In-vitro Model | 8505C | CVCL_1054 | Thyroid gland anaplastic carcinoma | Homo sapiens | ||
| TPC-1 | CVCL_6298 | Thyroid gland papillary carcinoma | Homo sapiens | |||
| Experimental
Result(s) |
The synergism between BIIB021 and triptolide in induction of cytotoxicity is associated with the inhibition of PI3K/Akt/mTOR and NF-KappaB signal pathways, the underexpression of survivin and the activation of DNA damage response in thyroid carcinoma cells. | |||||
