Drug Combination Details
| General Information of the Combination (ID: C86746) | |||||
|---|---|---|---|---|---|
| Name | Carnosic acid NP Info | + | Temozolomide Drug Info | ||
| Structure |
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| Disease |
Brain cancer
[ICD-11: 2A00]
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Investigative | [1] | ||
| Combinatorial Therapeutic Effect(s) Validated Clinically or Experimentally | ||||||
|---|---|---|---|---|---|---|
| α. Enhancing Drug Efficacy by This Combination | ||||||
| Augmenting Drug Sensitivity | Click to Show/Hide | |||||
| Experiment 1 Reporting the Effect of This Combination | [1] | |||||
| Molecule(s)
Regulation |
Down-regulation | Expression | AKT1 | Molecule Info |
Pathway MAP
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| Up-regulation | Cleavage | CASP3 | Molecule Info |
Pathway MAP
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| Down-regulation | Expression | CCNB1 | Molecule Info |
Pathway MAP
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| Up-regulation | Cleavage | PARP1 | Molecule Info |
Pathway MAP
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| Down-regulation | Expression | SQSTM1 | Molecule Info |
Pathway MAP
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| In-vitro Model | U-251MG | CVCL_0021 | Astrocytoma | Homo sapiens | ||
| LN-229 | CVCL_0393 | Glioblastoma | Homo sapiens | |||
| Experimental
Result(s) |
Carnosic acid potentiates the anticancer effect of temozolomide by inducing apoptosis and autophagy in glioma. | |||||
| References | ||||
|---|---|---|---|---|
| Reference 1 | Carnosic acid potentiates the anticancer effect of temozolomide by inducing apoptosis and autophagy in glioma. J Neurooncol. 2019 Jan;141(2):277-288. | |||
