Drug Combination Details
| General Information of the Combination (ID: C88508) | |||||
|---|---|---|---|---|---|
| Name | Cilostazol NP Info | + | Pravastatin Drug Info | ||
| Structure |
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+ |
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| Disease |
Atherosclerosis
[ICD-11: BD40]
|
Investigative | [1] | ||
| Combinatorial Therapeutic Effect(s) Validated Clinically or Experimentally | ||||||
|---|---|---|---|---|---|---|
| α. Enhancing Drug Efficacy by This Combination | ||||||
| Achieving Therapeutic Synergy | Click to Show/Hide | |||||
| Experiment 1 Reporting the Effect of This Combination | [1] | |||||
| Molecule(s)
Regulation |
Down-regulation | Expression | ICAM1 | Molecule Info |
Pathway MAP
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| In-vivo Model | For a xenograft model, Ten-week-old LDLR KO mice were fed a high-fat, high cholesterol diet. | |||||
| Experimental
Result(s) |
Combination therapy with pravastatin and cilostazol exerts beneficial effects by decreasing atherosclerotic lesion progression and improving the proinflammatory state in the vascular endothelium. | |||||
| References | ||||
|---|---|---|---|---|
| Reference 1 | Combination therapy with cilostazol and pravastatin improves antiatherogenic effects in low-density lipoprotein receptor knockout mice. Cardiovasc Ther. 2018 Dec;36(6):e12476. | |||
