Drug Combination Details
| General Information of the Combination (ID: C90807) | |||||
|---|---|---|---|---|---|
| Name | Gamma tocotrienol NP Info | + | Simvastatin Drug Info | ||
| Structure |
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+ |
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| Disease |
Breast cancer
[ICD-11: 2C60]
|
Investigative | [1] | ||
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Peritoneal cancer
[ICD-11: 2C51]
|
Investigative | [2] | |||
| Combinatorial Therapeutic Effect(s) Validated Clinically or Experimentally | ||||||
|---|---|---|---|---|---|---|
| α. Enhancing Drug Efficacy by This Combination | ||||||
| Achieving Therapeutic Synergy | Click to Show/Hide | |||||
| Experiment 1 Reporting the Effect of This Combination | [1] | |||||
| Molecule(s)
Regulation |
Down-regulation | Phosphorylation | AKT1 | Molecule Info |
Pathway MAP
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| Down-regulation | Phosphorylation | ERK2 | Molecule Info |
Pathway MAP
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| Down-regulation | Phosphorylation | JNK1 | Molecule Info |
Pathway MAP
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| Down-regulation | Phosphorylation | p38 beta | Molecule Info |
Pathway MAP
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| In-vitro Model | Neoplastic mouse +SA mammary epithelial cells | Healthy | Rattus norvegicus | |||
| Experimental
Result(s) |
Treatment with subeffective doses of simvastatin or gamma-tocotrienol alone had no effect, whereas combined treatment of these compounds resulted in a relatively large decrease in intracellular levels of phosphorylated (activated) MAPK, JNK, p38, and Akt. | |||||
| Experiment 2 Reporting the Effect of This Combination | [2] | |||||
| Biological
Regulation |
Inhibition | Mevalonate pathway | ||||
| In-vitro Model | NCI-H2052 | CVCL_1518 | Pleural sarcomatoid mesothelioma | Homo sapiens | ||
| NCI-H28 | CVCL_1555 | Pleural sarcomatoid mesothelioma | Homo sapiens | |||
| NCI-H2452 | CVCL_1553 | Pleural biphasic mesothelioma | Homo sapiens | |||
| MSTO-211H | CVCL_1430 | Pleural biphasic mesothelioma | Homo sapiens | |||
| Experimental
Result(s) |
Statin + Gamma-T3 combinations induced greater cell growth inhibition more than each single treatment via inhibition of mevalonate pathway, a well-known target of both Gamma-T3 and statins. | |||||
