Drug Combination Details
| General Information of the Combination (ID: C93360) | |||||
|---|---|---|---|---|---|
| Name | Genistein NP Info | + | Cetuximab Drug Info | ||
| Structure |
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+ |
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| Disease |
Lip/oral cavity/pharynx neoplasm
[ICD-11: 2B6E]
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Investigative | [1] | ||
| Combinatorial Therapeutic Effect(s) Validated Clinically or Experimentally | ||||||
|---|---|---|---|---|---|---|
| α. Enhancing Drug Efficacy by This Combination | ||||||
| Achieving Therapeutic Synergy | Click to Show/Hide | |||||
| Experiment 1 Reporting the Effect of This Combination | [1] | |||||
| Molecule(s)
Regulation |
Down-regulation | Phosphorylation | AKT1 | Molecule Info |
Pathway MAP
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| Down-regulation | Phosphorylation | EGFR | Molecule Info |
Pathway MAP
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| In-vitro Model | HSC-3 | CVCL_1288 | Tongue squamous cell carcinoma | Homo sapiens | ||
| KB | CVCL_0372 | Oral squamous cell carcinoma | Homo sapiens | |||
| In-vivo Model | HSC3 cells (1*107) were inoculated subcutaneously into the right flank of total eighty 6-8-week-old female BALB/c nude mice. | |||||
| Experimental
Result(s) |
Combined cetuximab and genistein treatment shows additive anti-cancer effect on oral squamous cell carcinoma. | |||||
| References | ||||
|---|---|---|---|---|
| Reference 1 | Combined cetuximab and genistein treatment shows additive anti-cancer effect on oral squamous cell carcinoma. Cancer Lett. 2010 Jun 1;292(1):54-63. | |||
