Drug Combination Details
| General Information of the Combination (ID: C94002) | |||||
|---|---|---|---|---|---|
| Name | 1,4-naphthoquinone | + | Imipenem + Cefuroxime + Cefotaxime | ||
| Click to Show/Hide the Each NP or Drug Information of This Combination | |||||
| Name | 1,4-naphthoquinone NP Info | Drug Info | |||
| Structure |
|
|
|||
| Name | Drug Info | ||||
| Structure |
|
|
|||
| Name | Drug Info | ||||
| Structure |
|
|
|||
| Disease |
Staphylococcus infection
[ICD-11: 1C41]
|
Investigative | [1] | ||
| Combinatorial Therapeutic Effect(s) Validated Clinically or Experimentally | ||||||
|---|---|---|---|---|---|---|
| α. Enhancing Drug Efficacy by This Combination | ||||||
| Achieving Therapeutic Synergy | Click to Show/Hide | |||||
| Experiment 1 Reporting the Effect of This Combination | [1] | |||||
| In-vitro Model | Micrococcus luteus | Microorganism model | Micrococcus luteus | |||
| Bacillus cereus | Microorganism model | Bacillus cereus | ||||
| Methicillin-sensitive Staphylococcus aureus | Microorganism model | Staphylococcus aureus | ||||
| Methicillin-Resistant Staphylococcus aureus | Microorganism model | Staphylococcus aureus | ||||
| Escherichia coli | Microorganism model | Escherichia coli | ||||
| Klebsiella pneumoniae | Microorganism model | Klebsiella pneumoniae | ||||
| Pseudomonas aeruginosa | Microorganism model | Pseudomonas aeruginosa | ||||
| Salmonella choleraesuis | Microorganism model | Salmonella choleraesuis | ||||
| Experimental
Result(s) |
1,4-naphthoquinone combined with ascorbate have significant antitumor effects against MCF-7 cells in vitro and Ehrlich-ascites carcinoma in mice. | |||||
