Drug Combination Details
| General Information of the Combination (ID: C94054) | |||||
|---|---|---|---|---|---|
| Name | Apocynin NP Info | + | Cyclophosphamide Drug Info | ||
| Structure |
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+ |
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| Disease |
Acute lung injury
[ICD-11: NB32]
|
Investigative | [1] | ||
| Combinatorial Therapeutic Effect(s) Validated Clinically or Experimentally | ||||||
|---|---|---|---|---|---|---|
| α. Decreasing Adverse Drug Reaction by This Combination | ||||||
| Decreasing Adverse Drug Reaction | Click to Show/Hide | |||||
| Experiment 1 Reporting the Effect of This Combination | [1] | |||||
| Molecule(s)
Regulation |
Up-regulation | Expression | AKT1 | Molecule Info |
Pathway MAP
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| Up-regulation | Expression | GABPA | Molecule Info | |||
| Up-regulation | Expression | GCLC | Molecule Info |
Pathway MAP
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| Up-regulation | Expression | HMOX1 | Molecule Info |
Pathway MAP
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| Down-regulation | Expression | KEAP1 | Molecule Info |
Pathway MAP
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| Up-regulation | Expression | mTOR | Molecule Info |
Pathway MAP
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| Up-regulation | Expression | PIK3CB | Molecule Info |
Pathway MAP
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| Up-regulation | Expression | SOD3 | Molecule Info | |||
| In-vivo Model | Male Wistar rats weighing 180-210 g were used in this study. | |||||
| Experimental
Result(s) |
Acetovanillone prevents cyclophosphamide-induced acute lung injury by modulating PI3K/Akt/mTOR and Nrf2 signaling in rats. | |||||
| References | ||||
|---|---|---|---|---|
| Reference 1 | Acetovanillone prevents cyclophosphamide-induced acute lung injury by modulating PI3K/Akt/mTOR and Nrf2 signaling in rats. Phytother Res. 2021 May 9. | |||
