Drug Combination Details
| General Information of the Combination (ID: C95159) | |||||
|---|---|---|---|---|---|
| Name | Picropodophyllin NP Info | + | Sorafenib Drug Info | ||
| Structure |
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+ |
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| Disease |
Hepatocellular carcinoma
[ICD-11: 2C12]
|
Investigative | [1] | ||
| Combinatorial Therapeutic Effect(s) Validated Clinically or Experimentally | ||||||
|---|---|---|---|---|---|---|
| α. Enhancing Drug Efficacy by This Combination | ||||||
| Achieving Therapeutic Synergy | Click to Show/Hide | |||||
| Experiment 1 Reporting the Effect of This Combination | [1] | |||||
| In-vitro Model | HLF | CVCL_2947 | Adult hepatocellular carcinoma | Homo sapiens | ||
| PLC/PRF/5 | CVCL_0485 | Adult hepatocellular carcinoma | Homo sapiens | |||
| Experimental
Result(s) |
Picropodophyllin and sorafenib synergistically suppress the proliferation and motility of hepatocellular carcinoma cells. | |||||
| References | ||||
|---|---|---|---|---|
| Reference 1 | Picropodophyllin and sorafenib synergistically suppress the proliferation and motility of hepatocellular carcinoma cells. Oncol Lett. 2014 Nov;8(5):2023-2026. | |||
