Drug Combination Details
| General Information of the Combination (ID: C95500) | |||||
|---|---|---|---|---|---|
| Name | Crocin NP Info | + | 5-fluorouracil Drug Info | ||
| Structure |
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+ |
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| Disease |
Colorectal cancer
[ICD-11: 2B91]
|
Investigative | [1] | ||
| Combinatorial Therapeutic Effect(s) Validated Clinically or Experimentally | ||||||
|---|---|---|---|---|---|---|
| α. Decreasing Adverse Drug Reaction by This Combination | ||||||
| Decreasing Adverse Drug Reaction | Click to Show/Hide | |||||
| Experiment 1 Reporting the Effect of This Combination | [1] | |||||
| In-vitro Model | CT26 | CVCL_7254 | Mouse colon adenocarcinoma | Mus musculus | ||
| In-vivo Model | Eight-week old female C57BL/6 mice were used in this study. | |||||
| Experimental
Result(s) |
Crocin synergistically enhances the antiproliferative activity of 5-flurouracil through Wnt/PI3K pathway in a mouse model of colitis-associated colorectal cancer. | |||||
