Drug Combination Details
| General Information of the Combination (ID: C96561) | |||||
|---|---|---|---|---|---|
| Name | Tocotrienols NP Info | + | Atorvastatin Drug Info | ||
| Structure |
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+ |
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| Disease |
Non alcoholic fatty liver disease
[ICD-11: DB92]
|
Phase 4 | [1] | ||
|
Colon cancer
[ICD-11: 2B90]
|
Investigative | [2] | |||
| Combinatorial Therapeutic Effect(s) Validated Clinically or Experimentally | ||||||
|---|---|---|---|---|---|---|
| α. Enhancing Drug Efficacy by This Combination | ||||||
| Achieving Therapeutic Synergy | Click to Show/Hide | |||||
| Experiment 1 Reporting the Effect of This Combination | [2] | |||||
| In-vitro Model | HT29 | CVCL_A8EZ | Colorectal adenocarcinoma | Mus musculus | ||
| HCT 116 | CVCL_0291 | Colon carcinoma | Homo sapiens | |||
| Experimental
Result(s) |
The synergistic actions of Gamma-T3 and ATST could be attributed to their mediation of 3-hydroxy-3-methyl-glutaryl-CoA reductase, and the subsequent inhibition of protein geranylgeranylation. | |||||
