Drug Combination Details
| General Information of the Combination (ID: C97041) | |||||
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| Name | Furanodiene + Curdione | + | Germacrone | ||
| Click to Show/Hide the Each NP or Drug Information of This Combination | |||||
| Name | Furanodiene NP Info | Drug Info | |||
| Structure |
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| Name | Curdione NP Info | ||||
| Structure |
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| Disease |
Breast cancer
[ICD-11: 2C60]
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Investigative | [1] | ||
| Combinatorial Therapeutic Effect(s) Validated Clinically or Experimentally | ||||||
|---|---|---|---|---|---|---|
| α. Enhancing Drug Efficacy by This Combination | ||||||
| Achieving Therapeutic Synergy | Click to Show/Hide | |||||
| Experiment 1 Reporting the Effect of This Combination | [1] | |||||
| Molecule(s)
Regulation |
Down-regulation | Expression | BCL-xL | Molecule Info |
Pathway MAP
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| In-vitro Model | MDA-MB-231 | CVCL_0062 | Breast adenocarcinoma | Homo sapiens | ||
| MCF-7 | CVCL_0031 | Invasive breast carcinoma | Homo sapiens | |||
| Experimental
Result(s) |
Germacrone enhanced furanodiene's anti-proliferative effect. | |||||
| References | ||||
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| Reference 1 | Impact of fixed-dose combination of germacrone, curdione, and furanodiene on breast cancer cell proliferation. Cell J. Summer 2013;15(2):160-5. | |||
