Natural Product (NP) Details

General Information of the NP (ID: NP2616)
Name
Curdione
Synonyms
Curdione; 13657-68-6; Germacr-1(10)-ene-5,8-dione; Cyclodecene-1,4-dione, 6,10-dimethyl-3-(1-methylethyl)-, (3S-(3R*,6E,10R*))-; SCHEMBL3297349; CHEBI:81131; HY-N0353; MFCD28977990; s9164; ZINC12153222; CCG-266841; 6-Cyclodecene-1,4-dione, 6,10-dimethyl-3-(1-methylethyl)-, (3S-(3R*,6E,10R*))- (9CI); AS-72874; N1432; C17493; Q15410914; (3S,6E,10S)-6,10-dimethyl-3-(propan-2-yl)cyclodec-6-ene-1,4-dione
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Species Origin Curcuma zedoaria ...     Click to Show/Hide
Curcuma zedoaria
Kingdom: Viridiplantae
Phylum: Streptophyta
Class: Magnoliopsida
Order: Zingiberales
Family: Zingiberaceae
Genus: Curcuma
Species: Curcuma zedoaria
Disease Renal cell carcinoma [ICD-11: 2C90] Phase 2 [1]
Structure
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2D MOL

3D MOL

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Formula
C15H24O2
PubChem CID
6441391
Canonical SMILES
CC1CCC=C(CC(=O)C(CC1=O)C(C)C)C
InChI
1S/C15H24O2/c1-10(2)13-9-14(16)12(4)7-5-6-11(3)8-15(13)17/h6,10,12-13H,5,7-9H2,1-4H3/b11-6+/t12-,13-/m0/s1
InChIKey
KDPFMRXIVDLQKX-NHFJXKHHSA-N
CAS Number
CAS 13657-68-6
ChEBI ID
CHEBI:81131
Herb ID
HBIN021993
SymMap ID
SMIT00200
TCMSP ID
MOL004255
Combinatorial Therapeutic Effect(s) Validated Clinically or Experimentally
    α. A List of Drug(s) Whose Efficacy can be Enhanced by This NP
          Germacrone      Idiopathic pulmonary fibrosis     Click to Show/Hide the Molecular Data of This Drug
                 Achieving Therapeutic Synergy     Click to Show/Hide
                    Representative Experiment Reporting the Effect of This Combination [2]
                    Detail(s)  Combination Info  click to show the detail info of this combination
                    Molecule(s)
                    Regulation		 Down-regulation Expression BCL-xL  Molecule Info 
Pathway MAP
                    In-vitro Model MDA-MB-231 CVCL_0062 Breast adenocarcinoma Homo sapiens
MCF-7 CVCL_0031 Invasive breast carcinoma Homo sapiens
                    Experimental
                    Result(s)		 Germacrone enhanced furanodiene's anti-proliferative effect.
    β. A List of Drug(s) Whose Adverse Effect can be Decreased by This NP
          Doxorubicin      Solid tumour/cancer     Click to Show/Hide the Molecular Data of This Drug
                 Decreasing Adverse Drug Reaction     Click to Show/Hide
                    Representative Experiment Reporting the Effect of This Combination [3]
                    Detail(s)  Combination Info  click to show the detail info of this combination
                    Molecule(s)
                    Regulation		 Down-regulation Expression BCL-2  Molecule Info 
Pathway MAP
                    In-vitro Model H9c2(2-1) CVCL_0286 Healthy Rattus norvegicus
                    Experimental
                    Result(s)		 Curdione ameliorated doxorubicin-induced cardiotoxicity through suppressing oxidative stress and activating Nrf2/HO-1 pathway.
References
Reference 1 ClinicalTrials.gov (NCT02626754) A Prospective Study on Sunitinib as First Line Therapy for Advanced/Metastatic Renal Cell Carcinoma in Asian Population
Reference 2 Impact of fixed-dose combination of germacrone, curdione, and furanodiene on breast cancer cell proliferation. Cell J. Summer 2013;15(2):160-5.
Reference 3 Curdione Ameliorated Doxorubicin-Induced Cardiotoxicity Through Suppressing Oxidative Stress and Activating Nrf2/HO-1 Pathway. J Cardiovasc Pharmacol. 2019 Aug;74(2):118-127.
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