Drug Combination Details
| General Information of the Combination (ID: C97853) | |||||
|---|---|---|---|---|---|
| Name | Plumbagin NP Info | + | Zoledronic Drug Info | ||
| Structure |
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+ |
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| Disease |
Breast cancer
[ICD-11: 2C60]
|
Investigative | [1] | ||
| Combinatorial Therapeutic Effect(s) Validated Clinically or Experimentally | ||||||
|---|---|---|---|---|---|---|
| α. Enhancing Drug Efficacy by This Combination | ||||||
| Achieving Therapeutic Synergy | Click to Show/Hide | |||||
| Experiment 1 Reporting the Effect of This Combination | [1] | |||||
| Molecule(s)
Regulation |
Down-regulation | Expression | BCL-2 | Molecule Info |
Pathway MAP
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| Up-regulation | Expression | NOTCH1 | Molecule Info |
Pathway MAP
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| In-vitro Model | MDA-MB-231 | CVCL_0062 | Breast adenocarcinoma | Homo sapiens | ||
| Experimental
Result(s) |
Combination of Zoledronic acid and Plumbagin synergistically suppresses human breast cancer MDA-MB-231SArfp cells in vitro. Plumbagin can inhibit Zoledronic acid-induced activation of the Notch-1 signaling pathway and subsequently reduce the expression of Bcl-2, thus potentiating cancer cell apoptosis. | |||||
| References | ||||
|---|---|---|---|---|
| Reference 1 | Synergistic suppression of human breast cancer cells by combination of plumbagin and zoledronic acid In vitro. Acta Pharmacol Sin. 2015 Sep;36(9):1085-98. | |||
