Drug Combination Details
| General Information of the Combination (ID: C98936) | |||||
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| Name | Fluoroorotic acid | + | Methioninase + 5-fluorouracil | ||
| Click to Show/Hide the Each NP or Drug Information of This Combination | |||||
| Name | Fluoroorotic acid NP Info | Drug Info | |||
| Structure |
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| Disease |
Acute lymphoblastic leukemia
[ICD-11: 2B33]
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Investigative | [1] | ||
| Combinatorial Therapeutic Effect(s) Validated Clinically or Experimentally | ||||||
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| α. Enhancing Drug Efficacy by This Combination | ||||||
| Achieving Therapeutic Synergy | Click to Show/Hide | |||||
| Experiment 1 Reporting the Effect of This Combination | [1] | |||||
| In-vitro Model | CCRF-CEM | CVCL_0207 | T acute lymphoblastic leukemia | Homo sapiens | ||
| Experimental
Result(s) |
Methioninase in combination with 5-fluorouracil and folinic acid showed cytotoxic synergism in CCRF-CEM. | |||||
| References | ||||
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| Reference 1 | Cytotoxic synergism of methioninase in combination with 5-fluorouracil and folinic acid. Biochem Pharmacol. 2001 Apr 1;61(7):867-76. | |||
