Drug Details

General Information of the Drug (ID: DR5679)
Name
Methioninase
Disease Breast cancer [ICD-11: 2C60] Investigative [1]
Combinatorial Therapeutic Effect(s) Validated Clinically or Experimentally
    α. A List of Natural Product(s) Able to Enhance the Efficacy of This Drug
          Fluoroorotic acid      Homo sapiens     Click to Show/Hide the Molecular Data of This NP
                 Achieving Therapeutic Synergy     Click to Show/Hide
                    Representative Experiment Reporting the Effect of This Combination [2]
                    Detail(s)  Combination Info  click to show the detail info of this combination
                    In-vitro Model CCRF-CEM CVCL_0207 T acute lymphoblastic leukemia Homo sapiens
                    Experimental
                    Result(s)		 Methioninase in combination with 5-fluorouracil and folinic acid showed cytotoxic synergism in CCRF-CEM.
References
Reference 1 Oral Methioninase Inhibits Recurrence in a PDOX Mouse Model of Aggressive Triple-negative Breast Cancer. In Vivo. Sep-Oct 2020;34(5):2281-2286.
Reference 2 Cytotoxic synergism of methioninase in combination with 5-fluorouracil and folinic acid. Biochem Pharmacol. 2001 Apr 1;61(7):867-76.
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