Drug Combination Details

General Information of the Combination (ID: C99275)
Name Paclitaxel   NP Info  + Temozolomide   Drug Info 
Structure +
Disease
Brain cancer [ICD-11: 2A00]
Investigative [1]
Combinatorial Therapeutic Effect(s) Validated Clinically or Experimentally
    α. Enhancing Drug Efficacy by This Combination
                 Achieving Therapeutic Synergy     Click to Show/Hide
                    Experiment 1 Reporting the Effect of This Combination [1]
                    Molecule(s)
                    Regulation		 Up-regulation Expression SLC2A1  Molecule Info 
Pathway MAP
                    In-vitro Model U-251MG CVCL_0021 Astrocytoma Homo sapiens
LN-229 CVCL_0393 Glioblastoma Homo sapiens
                    Experimental
                    Result(s)		 A combination of TMZ and Taxol exerted synergistic inhibitory effects on Taxol resistant glioma cells.
References
Reference 1 Combination of temozolomide and Taxol exerts a synergistic inhibitory effect on Taxol?resistant glioma cells via inhibition of glucose metabolism. Mol Med Rep. 2015 Nov;12(5):7705-11.
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