Drug Combination Details

General Information of the Combination (ID: C99442)
Name Mithramycin A   NP Info  + Vorinostat   Drug Info 
Structure +
Disease
Sezary T lymphoma [ICD-11: 2B02]
Investigative [1]
Combinatorial Therapeutic Effect(s) Validated Clinically or Experimentally
    α. Enhancing Drug Efficacy by This Combination
                 Achieving Therapeutic Synergy     Click to Show/Hide
                    Experiment 1 Reporting the Effect of This Combination [1]
                    In-vitro Model Primary tumor cells derived from Sezary syndrome patients Sezary syndrome Homo sapiens
                    Experimental
                    Result(s)		 MTR, like SAHA, induced the apoptosis of SS cells, while the two drugs in combination showed clear synergy or potentiation.
References
Reference 1 Vorinostat and Mithramycin A in combination therapy as an interesting strategy for the treatment of Sezary T lymphoma: a transcriptomic approach. Arch Dermatol Res. 2017 Oct;309(8):611-623.
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