Drug Details

General Information of the Drug (ID: DR1126)
Name
Risedronate
Synonyms
Risedronic acid; Risedronate; 105462-24-6; Atelvia; Risedronic acid monohydrate; Benet; NE-58095; UNII-KM2Z91756Z; (1-hydroxy-1-phosphono-2-pyridin-3-ylethyl)phosphonic acid; Phosphonic acid, [1-hydroxy-2-(3-pyridinyl)ethylidene]bis-; (1-hydroxy-1-phosphono-2-pyridin-3-yl-ethyl)phosphonic acid; Risedronic acid (Actonel); CHEMBL923; CHEBI:8869; Phosphonic acid, (1-hydroxy-2-(3-pyridinyl)ethylidene)bis-; [1-hydroxy-1-phosphono-2-(pyridin-3-yl)ethyl]phosphonic acid; 1-HYDROXY-2-(3-PYRIDINYL)ETHYLIDENE BIS-PHOSPHONIC ACID; KM2Z91756Z; RIS; (1-hydroxy-2-pyridin-3-ylethane-1,1-diyl)bis(phosphonic acid); Acido risedronico; Acide risedronique; Acidum risedronicum; Risedronic acid [INN:BAN]; (1-hydroxy-2-(pyridin-3-yl)ethane-1,1-diyl)bis(phosphonic acid); Acide risedronique [INN-French]; Acido risedronico [INN-Spanish]; Acidum risedronicum [INN-Latin]; 115436-72-1; Bisphosphonate 1; C7H11NO7P2.H2O; [1-hydroxy-1-phosphono-2-(3-pyridyl)ethyl]phosphonic acid; Ridron (TN); C7H11NO7P2; MFCD00867080; NE 58019; HSDB 7326; Risedronic acid (INN); 1-Hydroxy-2-(3-pyridyl)-ethan-1,1-bis-phosphonic acid; Risdronate; Risedronate acid; SR-05000001495; M05BA07; (1-Hydroxy-2-(3-pyridyl)ethylidene)diphosphonic acid; PubChem14002; SCHEMBL18378; BIDD:GT0010; GTPL3176; JMC515594 Compound 64; DTXSID2023563; BDBM12576; AMY3524; HMS2090C21; HMS3741A17; BCP13805; HY-B0148; ZINC1531009; 2689AH; s1874; AKOS015892564; AC-1295; CS-1964; DB00884; NCGC00386377-01; AS-13584; I802; AB0013898; FT-0642593; A11675; C08233; D08484; M-1366; AB01275490-01; AB01275490_02; 462R246; A801245; Q408724; SR-05000001495-1; 2-(3-pyridyl)-1-hydroxyethane-1,1-bisphosphonic acid; Z2684418685; (1-Hydroxy-2-(pyridin-3-yl)ethane-1,1-diyl)diphosphonic acid; (1-oxidanyl-1-phosphono-2-pyridin-3-yl-ethyl)phosphonic acid; [1-hydroxy-1-phosphono-2-(3-pyridinyl)ethyl]phosphonic acid; 1-hydroxy-2-(pyridin-3-yl)ethane-1,1-diyldiphosphonic acid
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Molecular Type
Small molecule
Disease Bone paget disease [ICD-11: FB85] Approved [1]
Structure
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2D MOL

3D MOL

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Formula
C7H11NO7P2
PubChem CID
5245
Canonical SMILES
C1=CC(=CN=C1)CC(O)(P(=O)(O)O)P(=O)(O)O
InChI
1S/C7H11NO7P2/c9-7(16(10,11)12,17(13,14)15)4-6-2-1-3-8-5-6/h1-3,5,9H,4H2,(H2,10,11,12)(H2,13,14,15)
InChIKey
IIDJRNMFWXDHID-UHFFFAOYSA-N
CAS Number
CAS 105462-24-6
ChEBI ID
CHEBI:8869
TTD Drug ID
D0PA5S
DrugBank ID
DB00884
Combinatorial Therapeutic Effect(s) Validated Clinically or Experimentally
    α. A List of Natural Product(s) Able to Decrease the Adverse Effect of This Drug
          Glucosamine      Homo sapiens     Click to Show/Hide the Molecular Data of This NP
                 Decreasing Adverse Drug Reaction     Click to Show/Hide
                    Representative Experiment Reporting the Effect of This Combination [2]
                    Detail(s)  Combination Info  click to show the detail info of this combination
                    In-vivo Model Rabbits quarantine OA was induced by anterior cruciate ligament transection (ACLT) and partial medial meniscectomy on one knee.
                    Experimental
                    Result(s)		 Glucosamine sulfate and risedronate treatment alone or in combination may be able to stop cartilage swelling. The risedronate treatment could partially stop the fibrillation and the inflammation of synovial membrane as well as modify the orientation of trabeculae in healthy and in osteoarthritic knees.
Target and Pathway
Target(s) Geranyltranstransferase (FDPS)  Molecule Info  [3]
BioCyc Superpathway of geranylgeranyldiphosphate biosynthesis I (via mevalonate) Click to Show/Hide
2 Superpathway of cholesterol biosynthesis
3 Trans, trans-farnesyl diphosphate biosynthesis
4 Geranylgeranyldiphosphate biosynthesis
KEGG Pathway Terpenoid backbone biosynthesis Click to Show/Hide
2 Metabolic pathways
3 Biosynthesis of antibiotics
4 Influenza A
5 HTLV-I infection
NetPath Pathway TCR Signaling Pathway Click to Show/Hide
Panther Pathway Cholesterol biosynthesis Click to Show/Hide
Pathwhiz Pathway Steroid Biosynthesis Click to Show/Hide
Reactome Cholesterol biosynthesis Click to Show/Hide
2 Activation of gene expression by SREBF (SREBP)
WikiPathways Activation of Gene Expression by SREBP (SREBF) Click to Show/Hide
2 SREBP signalling
3 Cholesterol Biosynthesis
References
Reference 1 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 3176).
Reference 2 Effects of glucosamine and risedronate alone or in combination in an experimental rabbit model of osteoarthritis. BMC Vet Res. 2014 Apr 26;10:97.
Reference 3 Activity of bisphosphonates against Trypanosoma brucei rhodesiense. J Med Chem. 2002 Jul 4;45(14):2904-14.
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