| Combinatorial Therapeutic Effect(s) Validated Clinically or Experimentally |
| α. Decreasing Adverse Drug Reaction by This Combination |
| Decreasing Adverse Drug Reaction |
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| Experiment 1 Reporting the Effect of This Combination |
[1] |
| In-vivo Model |
Rabbits quarantine OA was induced by anterior cruciate ligament transection (ACLT) and partial medial meniscectomy on one knee. |
Experimental
Result(s) |
Glucosamine sulfate and risedronate treatment alone or in combination may be able to stop cartilage swelling. The risedronate treatment could partially stop the fibrillation and the inflammation of synovial membrane as well as modify the orientation of trabeculae in healthy and in osteoarthritic knees. |
