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Drug Details

General Information of the Drug (ID: DR1235)
Name
Monodesbutyl benflumetol
Disease Malaria [ICD-11: 1F40] Investigative [1]
Combinatorial Therapeutic Effect(s) Validated Clinically or Experimentally
    α. A List of Natural Product(s) Able to Enhance the Efficacy of This Drug
          Retinol      Daucus carota     Click to Show/Hide the Molecular Data of This NP
                 Achieving Therapeutic Synergy     Click to Show/Hide
                    Representative Experiment Reporting the Effect of This Combination [2]
                    Detail(s)  Combination Info  click to show the detail info of this combination
                    In-vitro Model Plasmodium falciparum Microorganism model Plasmodium falciparum
                    In-vivo Model Clinical Trial
                    Experimental
                    Result(s)
Monodesbutyl-benflumetol and retinol combination showed synergistic interaction in Plasmodium falciparum.
References
Reference 1 Interaction between lumefantrine and monodesbutyl-benflumetol in Plasmodium falciparum in vitro. Wien Klin Wochenschr. 2008;120(19-20 Suppl 4):85-9.
Reference 2 Synergistic interaction between monodesbutyl-benflumetol and retinol in Plasmodium falciparum. Wien Klin Wochenschr. 2007;119(19-20 Suppl 3):53-9.
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Cite NPCDR
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Correspondence

X. N. Sun, Y. T. Zhang, Y. Zhou, X. C. Lian, L. L. Yan, T. Pan, T. Jin, H. Xie, Z. M. Liang, W. Q. Qiu, J. X. Wang, Z. R. Li, F. Zhu*, X. B. Sui*. NPCDR: natural product-based drug combination and its disease-specific molecular regulation. Nucleic Acids Research. 50(D1): 1324-1333 (2020). PMID: 34664659

Prof. Feng ZHU  (zhufeng@zju.edu.cn)

College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, China


Prof. Xinbing SUI  (hzzju@hznu.edu.cn)

School of Pharmacy and Department of Medical Oncology, the Affiliated Hospital of Hangzhou Normal University, Hangzhou Normal University, Hangzhou, China