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Drug Details

General Information of the Drug (ID: DR3743)
Name
Sucrose
Synonyms
sucrose; 57-50-1; saccharose; Cane sugar; Table sugar; White sugar; D-Sucrose; sugar; Rohrzucker; Saccharum; Granulated sugar; Amerfand; Amerfond; Microse; Beet sugar; Rock candy; Confectioner's sugar; Sucrose, dust; Sucrose, pure; D(+)-Saccharose; sacarosa; D-(+)-Sucrose; Sucraloxum [INN-Latin]; beta-D-Fructofuranosyl alpha-D-glucopyranoside; beta-D-Fructofuranosyl-alpha-D-glucopyranoside; D-(+)-Saccharose; CCRIS 2120; HSDB 500; Sacharose; alpha-D-Glucopyranosyl beta-D-fructofuranoside; CHEBI:17992; D-Saccharose; AI3-09085; (alpha-D-Glucosido)-beta-D-fructofuranoside; D(+)-Sucrose; alpha-D-Glucopyranoside, beta-D-fructofuranosyl; Fructofuranoside, alpha-D-glucopyranosyl, beta-D; Glucopyranoside, beta-D-fructofuranosyl, alpha-D; UNII-C151H8M554; MFCD00006626; alpha-D-Glucopyranoside, beta-D-fructofuranosyl-; NCI-C56597; 1-alpha-D-glucopyranosyl-2-beta-D-fructofuranoside; C151H8M554; beta-D-Fruf-(2<->1)-alpha-D-Glcp; NCGC00164248-01; DSSTox_CID_1288; NSC 406942; DSSTox_RID_76060; DSSTox_GSID_21288; D(+)-Sucrose, ACS reagent; Sucraloxum; Sucrose [USAN:JAN]; (+)-Sucrose; CAS-57-50-1; (2R,3R,4S,5S,6R)-2-(((2S,3S,4S,5R)-3,4-Dihydroxy-2,5-bis(hydroxymethyl)tetrahydrofuran-2-yl)oxy)-6-(hydroxymethyl)tetrahydro-2H-pyran-3,4,5-triol; (2R,3R,4S,5S,6R)-2-[(2S,3S,4S,5R)-3,4-dihydroxy-2,5-bis(hydroxymethyl)oxolan-2-yl]oxy-6-(hydroxymethyl)oxane-3,4,5-triol; (2R,3R,4S,5S,6R)-2-{[(2S,3S,4S,5R)-3,4-dihydroxy-2,5-bis(hydroxymethyl)oxolan-2-yl]oxy}-6-(hydroxymethyl)oxane-3,4,5-triol; D(+)-Sucrose, 99.7%, for biochemistry; FICOLL; Sucrose [JAN:NF]; EINECS 200-334-9; GLC-(1-2)FRU; Sucrose,ultrapure; D(+)-Sucrose, 99+%, for biochemistry, DNAse, RNAse and protease free; Compressible sugar; NSC-406942; Sucrose, purified; Sucrose, AR; Sucrose, LR; Sucrose, ultrapure; Sucrose, USP; Sucrose ACS grade; Sucrose (TN); Sugar spheres (NF); Sugar,(S); Sucrose, ACS reagent; Sucrose, reagent grade; 1af6; Sucrose (JP17/NF); Glc(alpha1->2beta)Fru; Sucrose Biochemical grade; Sucrose, SAJ first grade; Sugar, compressible (NF); bmse000119; bmse000804; bmse000918; Epitope ID:153236; Sucrose, >=99.5%; Sucrose, JIS special grade; White soft sugar (JP17); Sucrose, analytical standard; Sucrose, cell culture tested; Sugar, confectioner's (NF); 1-alpha-D-glucopyranosyl-2-beta-D-fructofranoside; 25702-74-3; Sucrose, p.a., ACS reagent; CHEMBL253582; GTPL5411; DTXSID2021288; CHEBI:65313; Sucrose, 1.2M aqueous solution; Sucrose, Molecular Biology Grade; GNE-410; Sucrose, >=99.5% (GC); S-67F; alpha-D-Glc-(1-2)-beta-D-Fru; 2-{[3,4-dihydroxy-2,5-bis(hydroxymethyl)oxolan-2-yl]oxy}-6-(hydroxymethyl)oxane-3,4,5-triol; HY-B1779; ZINC4217475; Tox21_112093; Tox21_201397; Tox21_300410; 5903AE; BDBM50108105; s3598; Sucrose, for electrophoresis, >99%; AKOS024306988; alpha-D-Glc-(1-->2)-beta-D-Fru; DB02772; MCULE-5933491732; Sucrose, BioXtra, >=99.5% (GC); a-D-Glucopyranosyl A-D-fructofuranoside; b -D-Fructofuranosyl a-D-glucopyranoside; NCGC00164248-02; NCGC00164248-03; NCGC00164248-05; NCGC00254237-01; NCGC00258948-01; 92004-84-7; Sucrose, meets USP testing specifications; Sucrose, Vetec(TM) reagent grade, 99%; D-Saccharose 1000 microg/mL in Methanol; alpha-D-Glucopyranosylbeta-D-fructofuranoside; CS-0013810; S0111; ST50308554; Sucrose, Grade I, plant cell culture tested; Sucrose, Grade II, plant cell culture tested; C00089; D00025; Sucrose, for molecular biology, >=99.5% (GC); Sucrose; ?-D-Fructofuranosyl ?-D-glucopyranoside; SR-01000883983; Sucrose, NIST(R) SRM(R) 17f, optical rotation; J-519846; Q4027534; SR-01000883983-1; Sucrose, for microbiology, ACS reagent, >=99.0%; alpha-D-glucopyranosyl-(1->2)-beta-D-fructofuranoside; Sucrose, British Pharmacopoeia (BP) Reference Standard; Sucrose, European Pharmacopoeia (EP) Reference Standard; Sucrose, Vetec(TM) reagent grade, RNase and DNase free; Z1601554751; alpha-D-Glucopyranoside, beta-D-fructofuranosyl, homopolymer; Sucrose, analytical standard, for enzymatic assay kit SCA20; UNII-YUH1C99228 component CZMRCDWAGMRECN-UGDNZRGBSA-N; Sucrose, anhydrous, free-flowing, Redi-Dri(TM), ACS reagent; Sucrose, BioUltra, for molecular biology, >=99.5% (HPLC); Sucrose, United States Pharmacopeia (USP) Reference Standard; Carbon isotopes in sucrose, NIST(R) RM 8542, IAEA-CH-6 sucrose; Compressible sugar, United States Pharmacopeia (USP) Reference Standard; Sucrose, puriss., meets analytical specification of Ph. Eur., BP, NF; WURCS=2.0/2,2,1/[ha122h-2b_2-5][a2122h-1a_1-5]/1-2/a2-b1; (2R,3R,4S,5S,6R)-2-((2S,3S,4S,5R)-3,4-dihydroxy-2,5-bis(hydroxymethyl)tetrahydrofuran-2-ylhydroxymethyl)tetrahydro-2H-pyran-3,4,5-triol; (2R,3R,4S,5S,6R)-2-((2S,3S,4S,5R)-3,4-dihydroxy-2,5-bis(hydroxymethyl)tetrahydrofuran-2-yloxy)-6-(hydroxymethyl)tetrahydro-2H-pyran-3,4,5-triol; (2R,3R,4S,5S,6R)-2-[(2S,3S,4S,5R)-3,4-dihydroxy-2,5-bis(hydroxymethyl)tetrahydrofuran-2-yl]oxy-6-(hydroxymethyl)tetrahydropyran-3,4,5-triol; 2-[(2S,3S,4S,5R)-2,5-bis(hydroxymethyl)-3,4-dihydroxyoxolan-2-yloxy](4S,5S,2R, 3R,6R)-6-(hydroxymethyl)-2H-3,4,5,6-tetrahydropyran-3,4,5-triol; 8027-47-2; 8030-20-4; 85456-51-5; 86101-30-6; 87430-66-8; Sucrose, BioReagent, suitable for cell culture, suitable for insect cell culture, >=99.5% (GC); Sucrose, Low Endotoxin, PharmaGrade, USP/NF, Ph Eur, Manufactured under appropriate GMP controls for pharma or biopharmaceutical production.
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Molecular Type
Small molecule
Disease Pain [ICD-11: MG30-MG3Z] Phase 4 [1]
Structure
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2D MOL

3D MOL

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Formula
C12H22O11
PubChem CID
5988
Canonical SMILES
C(C1C(C(C(C(O1)OC2(C(C(C(O2)CO)O)O)CO)O)O)O)O
InChI
1S/C12H22O11/c13-1-4-6(16)8(18)9(19)11(21-4)23-12(3-15)10(20)7(17)5(2-14)22-12/h4-11,13-20H,1-3H2/t4-,5-,6-,7-,8+,9-,10+,11-,12+/m1/s1
InChIKey
CZMRCDWAGMRECN-UGDNZRGBSA-N
CAS Number
CAS 57-50-1
ChEBI ID
CHEBI:17992
TTD Drug ID
D08TCV
DrugBank ID
DB02772
Combinatorial Therapeutic Effect(s) Validated Clinically or Experimentally
    α. A List of Natural Product(s) Able to Enhance the Efficacy of This Drug
          Xylitol      Saccharomyces cerevisiae     Click to Show/Hide the Molecular Data of This NP
                 Achieving Therapeutic Synergy     Click to Show/Hide
                    Representative Experiment Reporting the Effect of This Combination [2]
                    Detail(s)  Combination Info  click to show the detail info of this combination
                    In-vivo Model Obsborne-Mendel rats were inoculated once with a heavy suspension of S. mutans 50B4, serotype d, of human origin.
                    Experimental
                    Result(s)
This study confirms the suggested therapeutic effect of xylitol even when mixed with sucrose, while nonspecific effects were eliminated.
Target and Pathway
Target(s) Staphylococcus beta-lactamase (Stap-coc blaZ)  Molecule Info  [3]
References
Reference 1 ClinicalTrials.gov (NCT01293812) Effect on Pain of Oral Sucrose Versus Placebo in Children 1 to 3 Months Old Needing Venipuncture
Reference 2 Anti-cariogenic and remineralizing properties of xylitol in combination with sucrose in rats inoculated with Streptococcus mutans. Caries Res. 1984;18(3):269-77.
Reference 3 Ten S, Maclaren N: Insulin resistance syndrome in children. J Clin Endocrinol Metab. 2004 Jun;89(6):2526-39.
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Correspondence

X. N. Sun, Y. T. Zhang, Y. Zhou, X. C. Lian, L. L. Yan, T. Pan, T. Jin, H. Xie, Z. M. Liang, W. Q. Qiu, J. X. Wang, Z. R. Li, F. Zhu*, X. B. Sui*. NPCDR: natural product-based drug combination and its disease-specific molecular regulation. Nucleic Acids Research. 50(D1): 1324-1333 (2020). PMID: 34664659

Prof. Feng ZHU  (zhufeng@zju.edu.cn)

College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, China


Prof. Xinbing SUI  (hzzju@hznu.edu.cn)

School of Pharmacy and Department of Medical Oncology, the Affiliated Hospital of Hangzhou Normal University, Hangzhou Normal University, Hangzhou, China