Drug Details

General Information of the Drug (ID: DR4283)
Name
5-LOX shRNA
Molecular Type
Small hairpin RNA
Disease Prostate cancer [ICD-11: 2C82] Investigative [1]
Combinatorial Therapeutic Effect(s) Validated Clinically or Experimentally
    α. A List of Natural Product(s) Able to Enhance the Efficacy of This Drug
          Triptolide      Tripterygium hypoglaucum     Click to Show/Hide the Molecular Data of This NP
                 Achieving Therapeutic Synergy     Click to Show/Hide
                    Representative Experiment Reporting the Effect of This Combination [2]
                    Detail(s)  Combination Info  click to show the detail info of this combination
                    Molecule(s)
                    Regulation		 Down-regulation Expression VEGFA  Molecule Info 
Pathway MAP
                    In-vivo Model 1*107 SW1990 cells in 100 uL phosphate-buffered saline (PBS) were injected into back of BALB/c nude mice.
                    Experimental
                    Result(s)		 Triptolide augments the effects of 5-lipoxygenase RNA interference in suppressing pancreatic tumor growth in a xenograft mouse model.
Target and Pathway
Target(s) Influenza Neuraminidase (Influ NA)  Molecule Info  [3]
KEGG Pathway Other glycan degradation Click to Show/Hide
References
Reference 1 Pathogenesis in Bordetella species. J Infect Dis. 1990 Mar;161(3):581-3.
Reference 2 Triptolide augments the effects of 5-lipoxygenase RNA interference in suppressing pancreatic tumor growth in a xenograft mouse model. Cancer Chemother Pharmacol. 2012 Jan;69(1):253-61.
Reference 3 Laninamivir and its prodrug, CS-8958: long-acting neuraminidase inhibitors for the treatment of influenza. Antivir Chem Chemother. 2010;21(2):71-84.
 Download Picture         KEGG Link