Drug Details
| General Information of the Drug (ID: DR4283) | ||||
|---|---|---|---|---|
| Name |
5-LOX shRNA
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| Molecular Type |
Small hairpin RNA
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| Disease | Prostate cancer [ICD-11: 2C82] | Investigative | [1] | |
| Combinatorial Therapeutic Effect(s) Validated Clinically or Experimentally | ||||||
|---|---|---|---|---|---|---|
| α. A List of Natural Product(s) Able to Enhance the Efficacy of This Drug | ||||||
| Triptolide | Tripterygium hypoglaucum | Click to Show/Hide the Molecular Data of This NP | ||||
| Achieving Therapeutic Synergy | Click to Show/Hide | |||||
| Representative Experiment Reporting the Effect of This Combination | [2] | |||||
| Detail(s) |
Combination Info
click to show the detail info of this combination
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| Molecule(s)
Regulation |
Down-regulation | Expression | VEGFA | Molecule Info |
Pathway MAP
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| In-vivo Model | 1*107 SW1990 cells in 100 uL phosphate-buffered saline (PBS) were injected into back of BALB/c nude mice. | |||||
| Experimental
Result(s) |
Triptolide augments the effects of 5-lipoxygenase RNA interference in suppressing pancreatic tumor growth in a xenograft mouse model. | |||||
| Target and Pathway | ||||
|---|---|---|---|---|
| Target(s) | Influenza Neuraminidase (Influ NA) | Molecule Info | [3] | |
| KEGG Pathway | Other glycan degradation | Click to Show/Hide | ||
